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Application of wogonin in preparation of radiation sensitizer

A technology of wogonin and sensitizer, which is applied in the field of application of wogonin in the preparation of radiotherapy sensitizers, can solve the problems of low specificity, toxicity and side effects, etc., achieve broad application prospects, increase radiotherapy sensitivity, improve The effect of radiation therapy

Inactive Publication Date: 2018-08-10
SICHUAN CANCER HOSPITAL
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  • Claims
  • Application Information

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Problems solved by technology

There are several tumor radiosensitizers known in the prior art. In the process of realizing the present invention, the inventors have found that the prior art has the following problems: the radiosensitizers currently used in clinical practice include 5-fluorouracil (5-FU), Platinum, gemcitabine, DNA topoisomerase I inhibitors, etc., the principle of radiosensitization of these chemotherapeutic drugs is to inhibit the repair of DNA damage, block the cell cycle in the radiosensitive period or generate free radicals to damage tumor cells, but clinical application Problems such as low specificity, potential risks, and toxic side effects often occur in the process, so the invention of high-efficiency and low-toxic radiosensitizers has good social and economic benefits

Method used

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  • Application of wogonin in preparation of radiation sensitizer
  • Application of wogonin in preparation of radiation sensitizer
  • Application of wogonin in preparation of radiation sensitizer

Examples

Experimental program
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Embodiment 1

[0035] Establishment of breast cancer radiotherapy resistant cell model:

[0036] Firstly, the radiotherapy resistance phenotype of MCF / FIR cells was analyzed. The breast cancer cell lines MCF-7 and MCF / FIR were irradiated with 0, 2, 4, and 8 Gy of γ-rays respectively, and the CCK-8 (Cell Counting Kit) kit was used for cell counting. Proliferation activity detection and single-click multi-target model were used to evaluate the radiotherapy resistance of MCF / FIR cells; further, the tumor cell clone survival test was performed to evaluate the radiotherapy phenotype of MCF / FIR cells after 6 Gy of γ-ray irradiation for 1 hour.

[0037] The results showed that at the γ-ray radiation doses of 2, 4, and 8 Gy, the survival fraction of radiotherapy-resistant MCF / FIR cells was significantly higher than that of radiotherapy-sensitive MCF-7 cells (Pfigure 1 ).

[0038] Inhibition of Nrf2 expression enhances radiosensitivity of breast cancer cells:

[0039] Nrf2 is a key regulatory nuclea...

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Abstract

The invention discloses application of wogonin in preparation of a radiation sensitizer, and relates to application of wogonin in preparation of tumor cell Nrf2 inhibitors. The application of the wogonin in preparation of the radiation sensitizer is proposed for the first time; wogonin is capable of effectively improving the radiation sensitization of tumor cells, and thus the radiotherapy effectis improved; the action mechanism is related to wogonin inhibiting Nrf2 expression and increasing oxidative stress level and DNA damage in tumor cells; the wogonin has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of wogonin in the preparation of radiotherapy sensitizers. Background technique [0002] Radiotherapy is an important part of clinical treatment of tumors, but the effect of radiotherapy on tumors is affected by many factors. A large number of literature reports have shown that in various types of cancer, after long-term radiation exposure, tumor cells will be less sensitive and produce radioresistance, which will further cause tumor recurrence and metastasis, resulting in ineffective radiotherapy and disease progression. , has become a difficult problem in clinical radiotherapy. Radiosensitization refers to the use of physical methods, chemical substances or biological methods to increase the sensitivity of tumor cells to radiation, thereby increasing the killing effect on tumor cells. Some tumor radiosensitizers are known in the prior art. In the process of r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/352A61P35/00
Inventor 王婷蒋刚龙方懿
Owner SICHUAN CANCER HOSPITAL
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