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Pterostilbene toner

A technology of pterostilbene and skin rejuvenation lotion, which is applied in the directions of skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems such as the inability to meet the requirements of the solubility and stability of pterostilbene, and achieves improved skin absorption bioavailability, enhanced effect, stability improvement effect

Inactive Publication Date: 2018-08-07
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned natural small molecular substances that have been studied and reported as carriers can satisfy polyphenolic chemicals such as resveratrol and curcumin. However, the inventors found that the ginsenosides reported in the literature have , stevioside can not meet the solubility of pterostilbene and its aqueous solution stability requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Put 50mg of pterostilbene, 900mg of rebaudioside A, and 300mg of glycyrrhizic acid into a 100mL round-bottomed flask, add 50mL of absolute ethanol, and after fully dissolving, recover the absolute ethanol by rotary vacuum evaporation in a water bath at 40°C to obtain the drug and copolymer Disperse the film evenly, then add 10ml of distilled water, wash the film thoroughly, and ultrasonicate in a 300w water bath for 10min to obtain a micellar solution. After the micellar solution is aseptically filtered with a 0.22 μm microporous membrane, it can be aliquoted. The average particle size of the mixed nano-micelles encapsulating pterostilbene in the pterostilbene skin rejuvenation water is 7.5nm, the dispersion index PDI=0.005, and the dispersion uniformity is good as measured by the laser particle size analyzer. The pterostilbene skin rejuvenating water is stored at room temperature for 12 months, and the leakage of pterostilbene from micelles is less than 10%.

Embodiment 2

[0021] Put 100mg of pterostilbene, 3000mg of rebaudioside A, and 500mg of glycyrrhizic acid into a 100mL round-bottomed flask, add 50mL of absolute ethanol, fully dissolve, and recover the absolute ethanol by rotary vacuum evaporation in a water bath at 40°C to obtain the drug and copolymer Disperse the film evenly, then add 10ml of distilled water, wash the film thoroughly, and ultrasonicate in a 300w water bath for 10min to obtain a micellar solution. After the micellar solution is aseptically filtered with a 0.22 μm microporous membrane, it can be aliquoted. The average particle size of the mixed nano-micelles encapsulating pterostilbene in the pterostilbene rejuvenating water measured by laser particle size analyzer is 8.9nm, the dispersion index PDI=0.006, and the dispersion uniformity is good. The pterostilbene skin rejuvenating water is stored at room temperature for 12 months, and the leakage of pterostilbene from micelles is less than 10%.

Embodiment 3

[0023] Put 20mg of pterostilbene, 300mg of rebaudioside A, and 50mg of glycyrrhizic acid into a 100mL round-bottomed flask, add 50mL of absolute ethanol, and after fully dissolving, recover the absolute ethanol by rotary vacuum evaporation in a water bath at 40°C to obtain the drug and copolymer Disperse the film evenly, then add 10ml of distilled water, wash the film thoroughly, and ultrasonicate in a 300w water bath for 10min to obtain a micellar solution. After the micellar solution is aseptically filtered with a 0.22 μm microporous membrane, it can be aliquoted. The average particle diameter of the mixed nano-micelles encapsulating pterostilbene in the pterostilbene rejuvenating water measured by laser particle size analyzer is 8.2nm, the dispersion index PDI=0.008, and the dispersion uniformity is good. The pterostilbene skin rejuvenating water is stored at room temperature for 12 months, and the leakage of pterostilbene from micelles is less than 10%.

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Abstract

The invention relates to a high-stability pterostilbene toner capable of providing a faintly acid nano-micelle micro-environment. The high-stability pterostilbene toner contains pterostilbene as maincomponent, and is characterized by containing Rebaudioside A and glycyrrhizic acid as auxiliaries, wherein the mass ratio between pterostilbene and Rebaudioside A is 1:15-1:30, and the mass ratio between glycyrrhizic acid and Rebaudioside A is 1:3-1:6. According to the pterostilbene toner, Rebaudioside A and glycyrrhizic acid spontaneously form micelle to solubilize pterostilbene, so as to improvethe stability of pterostilbene, and form a high-stability pterostilbene aqueous solution; the solubility of pterostilbene reaches 15mg / ml, micelle grain size is small and uniform in distribution, andthe toner storage stability is good. Rebaudioside A and glycyrrhizic acid have the skincare effect, and after solubilization of pterostilbene, the skin care activity of the pterostilbene toner is enhanced in a synergetic way, so as to achieve a goof skin elasticity maintaining effect.

Description

technical field [0001] The present invention relates to a skin rejuvenation lotion containing pterostilbene, in particular to a skin-rejuvenating water with the effects of whitening, anti-inflammation, anti-oxidation, anti-aging, moisturizing and clear, restoring cell vitality and maintaining skin elasticity. Highly stable pterostilbene complex rejuvenating water for microenvironment. Background technique [0002] Oxidation is the biggest threat to skin aging. Various factors can cause free radicals to flood the skin, resulting in oxidative phenomena such as dull complexion and dehydration. So we need to pay attention to antioxidants in our daily skin care. The anti-oxidation of the face is to use the skin care screen to exclude the damage to the skin from the external environment, such as radiation and air, and to slow down the natural aging of the age, so that the face will not produce obvious wrinkles and other skin problems. In daily skin care products, adding anti-oxi...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/60A61K8/63A61K8/11A61Q19/00A61Q17/00A61Q17/04A61Q19/02A61Q19/08
CPCA61Q17/00A61Q17/04A61Q19/00A61Q19/02A61Q19/08A61K8/11A61K8/347A61K8/602A61K8/63A61K2800/56A61K2800/413
Inventor 吴祥根张凡王惠
Owner QINGDAO UNIV OF SCI & TECH
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