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Preparation method of high-performance polyvinyl alcohol hydrogel artificial cartilage substitute material

A technology of polyvinyl alcohol and hydrogel, which is applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems that the mechanical strength of human cartilage cannot be met, and the improvement of PVA mechanical strength is small, so as to improve the biomechanical strength , easy to functional modification, improve the effect of mechanical strength and toughness

Active Publication Date: 2020-09-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reported literature has a small increase in the mechanical strength of PVA, which still cannot meet the requirements of the human body for the mechanical strength of cartilage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Disperse 0.05g of graphite in 50g of deionized water, add 0.05g of amino-terminated polyoxyethylene ether with a molecular weight of 2000g / mol, stir evenly at room temperature, and disperse with ultrasonic waves for 30min, with ultrasonic power of 500w, frequency of 20000HZ, and ultrasonic temperature of 50°C. Obtain coupling treatment graphite dispersion liquid.

[0021] Weigh 10 g of polyvinyl alcohol with a degree of polymerization of 1300 and a degree of alcoholysis of 99%, add it to the coupling-treated graphite dispersion prepared above, heat and stir at 85°C for 5 hours to prepare a uniform composite solution; pour the solution into a mold , placed at -10°C for 8 hours, then placed in a constant temperature and humidity box to thaw for 2 hours, cycle freezing-thawing 4 times; Stretching and orientation under stress to prepare an orientation composite hydrogel with an orientation ratio of 150%, sealed in bags, and stored in a 4°C refrigerator for later use; the te...

Embodiment 2

[0023] Disperse 0.5g of graphene in 800g of deionized water, add 0.38g of hydroxyl-terminated polydimethylsiloxane with a molecular weight of 20,000g / mol, stir evenly at room temperature, and disperse with ultrasonic waves for 90min with ultrasonic power of 1000w and frequency of 40,000HZ. The temperature is 75° C., and the coupling treated graphene dispersion is obtained.

[0024] Weigh 10g of polyvinyl alcohol with a degree of polymerization of 1700 and a degree of alcoholysis of 88% and add it to the above-prepared coupling-treated graphene dispersion, heat and stir at 90°C for 3.5 hours to prepare a uniform composite solution; pour the solution into a mold Freeze at -30°C for 12 hours, then thaw in a constant temperature and humidity box for 6 hours, cycle freezing-thawing 6 times; Tensile stress was used for stretching and orientation, and an orientation composite hydrogel with an orientation ratio of 300% was prepared, packaged in sealed bags, and stored in a 4°C refrige...

Embodiment 3

[0026] Disperse 1.5g of carbon nanotubes in 2000g of deionized water, add 0.8g of aminoethylaminopropyl polydimethylsiloxane with a molecular weight of 40000g / mol, stir evenly at room temperature, and disperse with ultrasonic waves for 150min. The ultrasonic power is 2000w, frequency The ultrasonic temperature is 60000HZ, and the ultrasonic temperature is 90° C. to obtain a coupling-treated carbon nanotube dispersion.

[0027] Weigh 10 g of polyvinyl alcohol with a degree of polymerization of 2000 and a degree of alcoholysis of 99%, add it to the above-prepared coupling-treated carbon nanotube dispersion, heat and stir at 95°C for 3 hours to prepare a uniform composite solution; pour the solution into In the mold, freeze at -50°C for 16 hours, then thaw in a constant temperature and humidity box for 8 hours, cycle freezing-thawing 8 times; after cycle freezing-thawing once, fix both ends of the sample on the tensile fixture, apply Tensile stress was used for stretching and ori...

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Abstract

The invention discloses a preparation method of a high-performance polyvinyl alcohol (PVA) hydrogel artificial cartilage substitute material. The preparation method is characterized in that the characteristics of high strength, excellent wear-resisting self-lubrication property and easy functional modification of a carbon nanomaterial are utilized, functional coupling agents having an active functional group and an excellent self-lubrication property like polyethylene oxide and polysiloxane are used to implement coupling treatment on the surface of the carbon nanomaterial, a PVA / carbon nanomaterial nanocomposite gel is studied and prepared, carbon nanoparticles are excellently dispersed in a PVA matrix, the roles of the functional coupling agent in coupling, increasing capacity, and synergistically enhancing with the carbon nanoparticle, and reducing friction are played; the composite gel is stretched and oriented on the basis to form a molecular orientation structure, the mechanical toughness is further improved, and the service life is prolonged.

Description

technical field [0001] The invention relates to a preparation method of a high-performance polyvinyl alcohol hydrogel artificial cartilage substitute material, belonging to the field of polymer material preparation. Background technique [0002] Joints are an important part of the human musculoskeletal system, and are the basis for the human body to maintain normal life and sports; articular cartilage plays an important role in joint activities, and has good mechanical strength and toughness due to high pressure stress; at the same time, articular cartilage also has Excellent lubrication system, which can protect the bone under the cartilage from damage. [0003] Porous polyvinyl alcohol (PVA) hydrogel with similar natural cartilage tissue is considered to be an ideal material for cartilage replacement, with non-toxic, no side effects, excellent biocompatibility, stable chemical properties, good flexibility and high Elasticity can reduce mechanical stimulation to surroundin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/52C08J9/28C08J3/075C08L29/04C08K9/04C08K9/06C08K7/24C08K3/04
CPCA61L27/443A61L27/50A61L27/52A61L2400/12A61L2430/06C08J3/075C08J9/28C08J2201/0484C08J2329/04C08K3/04C08K7/24C08K9/08C08K2201/011C08L29/04C08L71/02C08L83/04
Inventor 叶林孟烨桥赵晓文
Owner SICHUAN UNIV
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