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A kind of blood lipid-lowering pharmaceutical composition and its application

A composition and drug technology, applied in the field of medicine, can solve the problems of poor curative effect, large toxic and side effects, and achieve the effects of no allergic reaction, high safety, and no bleeding

Active Publication Date: 2020-06-09
石药集团明复乐药业(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problems of large toxic and side effects and poor curative effect of existing blood lipid-lowering drugs, the object of the present invention is to provide a blood lipid-lowering pharmaceutical composition, which contains rhTNK-tPA, sodium alginate diester and pantethine

Method used

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  • A kind of blood lipid-lowering pharmaceutical composition and its application
  • A kind of blood lipid-lowering pharmaceutical composition and its application
  • A kind of blood lipid-lowering pharmaceutical composition and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0028] The preparation of embodiment 1 compound freeze-dried powder injection

[0029] components Dosage rhTNK-tPA 5g Sodium alginate diester 50g pantethine 12.5g arginine 5g pH regulator Appropriate amount Water for Injection 1000mL

[0030] Preparation:

[0031] (1) mix rhTNK-tPA, sodium alginate diester, pantethine, arginine and a pH regulator with water for injection according to the proportion, and adjust the pH value to 7.0 to obtain a medicinal solution;

[0032] (2) Sterilize and filter the medicinal liquid prepared in step (1) into vials, and wait for the plate temperature of the lyophilizer to be pre-frozen to below -10°C, put the vial samples to be lyophilized into the freeze-drying box, Insulate below -35°C for 2 hours, start vacuuming, after the vacuum degree is lower than 80Pa, raise the temperature of the board layer to -15°C, maintain the vacuum degree below 80Pa, start to heat up when the visible water line...

Embodiment 2

[0033] The preparation of embodiment 2 compound freeze-dried powder injection

[0034] components Dosage rhTNK-tPA 2.5g Sodium alginate diester 50g pantethine 10g arginine 3.5g pH regulator Appropriate amount Water for Injection 1000mL

[0035] The preparation method refers to Example 1.

Embodiment 3

[0036] The preparation of embodiment 3 compound freeze-dried powder injection

[0037] components Dosage rhTNK-tPA 3.75g Sodium alginate diester 50g pantethine 15g arginine 5.25g pH regulator Appropriate amount Water for Injection 1000mL

[0038] The preparation method refers to Example 1.

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Abstract

The invention relates to the technical field of medicine, in particular to a blood lipid-lowering pharmaceutical composition and use thereof. The blood lipid-lowering pharmaceutical composition comprises recombinant human tissue plasminogen activator TNK mutant rhTNK-tPA, sodium alginate diester and pantethine. The recombinant human tissue plasminogen activator TNK mutant rhTNK-tPA, sodium alginate diester and pantethine are formed in a mass ratio of (0.05-0.1):1:(0.2-0.3), preferably is composed of a mass ratio of 0.1:1:0.25. The blood lipid-lowering pharmaceutical composition provided by the invention can effectively reduce the levels of total cholesterol, triglyceride and low-density lipoprotein in serum, and increase the level of high-density lipoprotein in serum, has a significant blood-lipid lowering effect, and is superior to any of the compositions in the composition. A single drug. And the incidence of adverse events is low, no allergic reaction, no bleeding phenomenon, high safety.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a blood lipid-lowering pharmaceutical composition and use thereof. Background technique [0002] Hyperlipidemia is the abnormality of fat metabolism or functioning that makes one or more lipids in plasma higher than normal. It is a systemic disease with high blood total cholesterol (TC) and (or) triglycerides or low high-density lipoprotein cholesterol (HDL-C), which is called dyslipidemia in modern medicine, and is often referred to as hyperlipidemia. Lipoproteinemia. Most hyperlipidemias do not have any symptoms in the early stage. If they are not corrected in time, they will cause gradual and progressive systemic damage to the body. It accelerates systemic atherosclerosis, which in turn causes kidney failure. Current data and research show that hyperlipidemia can induce the following diseases: coronary heart disease, myocardial infarction, sudden cardiac death, stroke, hyp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/49A61P3/06A61K31/16A61K31/737
CPCA61K31/16A61K31/737A61K38/49C12Y304/21068A61K2300/00
Inventor 杨琴胡家华王森穆国会曹靖文
Owner 石药集团明复乐药业(广州)有限公司
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