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New application of barley leaves

A barley leaf and drug technology, applied in the new use field of barley leaf, can solve the problems of difficult to control the epidemic trend of inflammatory bowel disease and the safety defect of drug therapy, so as to improve the intestinal microenvironment and improve the intestinal barrier function. , the effect of inhibiting weight loss

Inactive Publication Date: 2018-07-24
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, anti-inflammatory drugs and immunosuppressants are the main treatments for inflammatory bowel disease, however drug therapy still has many shortcomings in terms of therapeutic effect and safety
Therefore, it is difficult to control the prevalence of inflammatory bowel disease worldwide with a simple treatment plan, and it is urgent to find new safe and effective ways to prevent inflammatory bowel disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Barley leaves can improve inflammatory bowel disease in mice

[0031] Taking dextran sodium sulfate (DSS)-induced colitis in mice as a research model, the model is established as follows:

[0032] 5-week-old healthy female C57BL / 6J mice were selected and raised in a standard 12-hour day-night cycle, constant temperature at 22°C, and a specific pathogen-free (SPF) environment. After one week of adaptive feeding, the mice were randomly divided into a control group (CT, 12 mice) and a barley leaf group (BL, 12 mice). The mice in the control group were fed normal mouse diet (Research diet, D12450B). The mice in the barley leaf group were fed with normal mouse diet supplemented with 2.5% barley leaf by mass. Each mouse was fed with 0.3g feed per day, and after 3 weeks of continuous feeding, DSS was added to the drinking water of the two groups of mice at a ratio of 2.5% mass fraction, and the mice were allowed to drink water freely for 7 days to induce colitis. ...

Embodiment 2

[0038] Example 2: Barley leaves can improve the intestinal microenvironment of mice induced by DSS

[0039] Using the DSS-induced colitis in mice in Example 1 as a research model, the effect of barley leaves on the structure of the intestinal microbial flora was explored.

[0040] There are a large number of microbial populations living in the intestinal tract of animals. The number of microorganisms in the intestinal tract of adults is as high as 1014, which is 10 times the number of human somatic cells, and the number of genomes is about 100 times that of the human genome. As the largest and most complex microecosystem in animals, gut microbes play important physiological functions, such as metabolizing and degrading dietary nutrients, preventing pathogen invasion, and maintaining the homeostasis of the intestinal microenvironment. Studies have shown that gut microbes play an important regulatory role in the occurrence and development of inflammatory bowel disease. The imba...

Embodiment 3

[0046] Example 3: Barley leaves can promote the proliferation of intestinal epithelial cells in healthy mice

[0047] 5-week-old healthy female C57BL / 6J mice were selected and raised in a standard 12-hour day-night cycle and a constant temperature of 22°C in a specific pathogen-free (SPF) environment. After 1 week of adaptive feeding, the mice were randomly divided into a control group (CT′, 12 mice) and a barley leaf group (BL′, 12 mice). The mice in the control group were fed normal mouse diet (Research diet, D12450B ), and the mice in the barley leaf group were fed with normal mouse diet supplemented with 2.5% barley leaf by mass.

[0048] Each mouse was fed with 0.3g feed every day, and after continuous feeding for 3 weeks, the mice were dissected, and the colon tissue samples were preserved with 4% formalin fixative, and stained with hematoxylin & eosin (H&E) To detect the morphological changes of mouse colonic epithelial cells, specifically as Figure 7 as shown, Fig...

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Abstract

The invention belongs to the technical field of nutrient supplementing of dietary foods, and particularly relates to new application of barley leaves. The new application has the advantages that the intestines diseases are treated and / or prevented by the barley leaves through inhibiting the colitis symptoms of the DSS (dextran sulphate sodium)-induced mouse, such as diarrhea and hematochezia; themicroenvironment of intestines is improved by regulating the composition of intestine flora, the proliferation of enterocytes and the increasing of intestinal mucus are promoted, and the intestine barrier function is improved; the obvious promotion function on the application of the barley leaves on market is realized, and a novel intestine dietary intervention path is favorably opened.

Description

technical field [0001] The invention belongs to the technical field of dietary food nutritional supplements, and in particular relates to a new application of barley leaves. Background technique [0002] Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammatory disorder characterized by weight loss, severe diarrhea, and abdominal pain. [0003] Inflammatory bowel disease was first established as a formal medical term by Wilks and Moxon in 1875. In the early 20th century, the incidence of ulcerative colitis gradually increased. In 1932, Crohn's article published in the journal JAMA introduced the concept of regional ileitis, allowing the medical community to distinguish between two different forms of inflammatory bowel disease, namely Crohn's disease and ulcerative colitis inflammation. Since the middle of the 20th century, Crohn's disease and ulcerative colitis have mainly occurred in Western countries such as...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P1/12A61P1/00A61P1/04A23L33/105A61K127/00
CPCA23V2002/00A61K36/8998A23L33/105A23V2200/32
Inventor 陈芳李道通丰宇孙慧慧廖小军胡小松
Owner CHINA AGRI UNIV
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