Alkaline effervescent tablets for treating gout and hyperuricemia
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An effervescent tablet, high uric acid technology, applied in the direction of bone diseases, organic active ingredients, medical preparations with non-active ingredients, etc. Addition and subtraction, high cost of granule preparation, to achieve obvious synergistic effect, easy to take, quick effect
Inactive Publication Date: 2018-07-20
光谷迈德(武汉)慢性病研究院有限公司
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Problems solved by technology
Existing citrate for the treatment of gout and hyperuricemia disease is usually common granules, and its existing problems are as follows: the preparation cost of granules is high, the mobility is poor, and it is impossible to follow up and subtract, and the existing Citrate granules for the treatment of gout and hyperuricemia are medicines, which are taken in large doses and have relatively large side effects
In the prior art, there is no alkaline effervescent tablet that can provide a large amount of citrate after dissolving, and there is no alkaline effervescent tablet that can be used to treat gout and hyperuricemia diseases
Method used
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Embodiment 1
[0024] An alkaline effervescent tablet for patients with gout and hyperuricemia, prepared from the following raw materials: 31.5 kg of citric acid, 21 kg of sodium bicarbonate, 3 kg of sodium citrate, 5 kg of potassium citrate, and 4.9 kg of sorbitol , lactose 0.7kg, acerola cherry extract 1.4kg, polyethylene glycol 0.7kg, sucralose 0.4kg, lemon flavor 1.4kg. It can be made into 20,000 pieces.
[0025] Preparation:
[0026] (a) Mix and pulverize citric acid, sorbitol and lactose through an 80-mesh sieve, put them in a mixer, moisten them with polyethylene glycol, make soft materials, wet granulate, blow at 56°C for 55 minutes on an ebullated bed, and dry them Prepare the first granule and keep the whole granule for later use.
[0027] (b) Sodium bicarbonate, sodium citrate and potassium citrate are mixed and pulverized through a 100-mesh sieve, placed in a mixer, wetted with polyethylene glycol to make a soft material, wet granulated, blown at 56°C in an ebullated bed After...
Embodiment 2
[0033] An alkaline effervescent tablet for patients with gout and hyperuricemia, prepared from the following raw materials: 31.5 kg of citric acid, 21 kg of sodium bicarbonate, 8 kg of potassium citrate, 4.9 kg of sorbitol, 0.7 kg of lactose, Acerola cherry extract 1.4kg, polyethylene glycol 0.7kg, sucralose 0.4kg, lemon essence 1.4kg. It can be made into 20,000 pieces.
[0034] Preparation:
[0035] (a) Mix and pulverize citric acid, sorbitol and lactose through an 80-mesh sieve, put them in a mixer, moisten them with polyethylene glycol, make soft materials, wet granulate, blow at 56°C for 55 minutes on an ebullated bed, and dry them Prepare the first granule and keep the whole granule for later use.
[0036] (b) Sodium bicarbonate and potassium citrate are mixed and pulverized through a 100-mesh sieve, placed in a mixer, wetted with polyethylene glycol, made into a soft material, wet granulated, blown at 56°C for 55 minutes on an ebullated bed, and dried to make a soft ma...
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Abstract
The invention relates to alkaline effervescent tablets for treating gout and hyperuricemia, and a preparation method of alkaline effervescent tablets. The alkaline effervescent tablets are prepared from the following raw materials by mass percent: 45-55% of citric acid, 30-40% of an alkali source, 7-15% of citrate, 2-4% of an acerola cherry extract, 3-8% of a filling agent, 0.8-1.4% of a lubricant, 0.5-0.8% of sucralose and 1-2% of lemon essence; the preparation method comprises the following steps: mixing the citric acid and the filling agent with a right amount of the lubricant to prepare first granules; preparing second granules by using the alkali source, the citrate and a right amount of the lubricant; then, evenly mixing the first granules and the second granules with the rest components, and tabletting to obtain the alkaline effervescent tablets. The alkaline effervescent tablets have the advantages that the alkaline effervescent tablets for treating the gout and the hyperuricemia are provided for the first time, and are convenient to take, less in gastrointestinal irritation and easy to absorb; due to the cooperation of the citrate and the acerola cherry extract in the alkaline effervescent tablets, the alkaline effervescent tablets are good in urine alkalization effect.
Description
technical field [0001] The invention belongs to the field of medicines for treating gout and high uric acid diseases, and in particular relates to an alkaline effervescent tablet which can be used for treating gout and high uric acid diseases. Background technique [0002] In recent years, with changes in lifestyle, the incidence of hyperuricemia and gout has increased year by year, and hyperuricemia has become the "fourth highest" after hypertension, hyperglycemia, and hyperlipidemia. A meta-analysis that integrates epidemiological research data from multiple regions in China shows that the prevalence of gout in China is as high as 1.1%, and the prevalence of hyperuricemia is as high as 13.3%, and the prevalence of gout and hyperuricemia are increasing year by year . At present, the pathogenesis of gout has not been fully clarified, but hyperuricemia is its main physiological basis, so the main goal of gout management is to reduce and maintain the serum uric acid concentra...
Claims
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Application Information
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