Application of leonurine in preparing euglycemic agent

Abstract

The invention belongs to the field of modern traditional Chinese medicine production, and relates to Chinese herbal medicine herba leonuri extract leonurine and application of the leonurine in preparing drugs, in particular to application of the leonurine in preparing a euglycemic agent and preventing the obesity. Through the pharmacological study and insulin sensibilization experiments, the results show that the leonurine has the effect of improving the sensibility of insulin in the body, and the leonurine can enhance the reaction of the body to the insulin, enhance the physiological effect of the insulin and increasing the sensibility of an insulin receptor; the experimental results show that under the condition that the leonurine is far lower than the toxic dose, the effect of reducingthe body weight is shown. The leonurine can be used for preparing the euglycemic agent and the drugs for preventing the obesity and is especially suitable for etiological treatment of the insulin resistance syndrome and the secondary disease symptoms caused by reduction of insulin resistance or insulin sensitivity, such as the central obesity, the simple obesity and the obesity with any other disease states.

Description

technical field [0001] The invention belongs to the field of modern pharmaceuticals of traditional Chinese medicine, and relates to a kind of motherwort extract of Chinese herbal medicine motherwort and its application in the preparation of medicines, especially its use in the preparation of insulin sensitizers, and the insulin sensitizers are especially suitable for treating insulin resistance syndrome sign. Background technique [0002] Studies have shown that insulin resistance syndrome is a basic disease that causes a series of functional and structural disorders and lesions of the body due to the reduced reactivity or sensitivity of the body to the physiological effects of insulin. Studies have shown that insulin resistance syndrome is a basic disease that causes a series of functional and structural disorders and lesions of the body due to the reduced reactivity or sensitivity of the body to the physiological effects of insulin. The industry believes that the disease ...

AI Technical Summary

Problems solved by technology

[0003] Clinical practice shows that the above-mentioned problems have indeed been paid attention to by the predecessors, and insulin sensitizers have been invented, which are specially used for the treatment of insulin resistance syndrome, and provide a powerful technical means for the development of precision medicine for the cause of treatment. The drug is Thiazolidinedione derivatives, whose first drug is troglitazone (Troglitagone’s trade name Rezulin), the invention of this drug was once placed high expectations by the medical community, and it was believed that there was finally an effective treatment for insulin resistance syndrome However, thiazolidinedione derivatives have been withdrawn from the global market since 2000 due to serious hepatotoxicity and cardiovascular events, including heart failure and severe edema, in clinical application. Toxic alternatives come out

[0004] Motherwort (Labiatae, Herba Leonuri , Chinese Motherwort) was first recorded in ancient books such as "Shen Nong's Materia Medica", "Compendium of Materia Medica", and has the effects of promoting blood circulation, regulating menstruation, diuresis and reducing swelling; closed, endless lochia, edema, oliguria, acute nephritis edema, etc.; there is no report on the application of motherwort as an insulin sensitizer

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