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Disposable nanopore biosensor and manufacturing method thereof

A biosensor and nanopore technology, applied in instruments, scientific instruments, measuring devices, etc., can solve the problems of complex operation of disposable sensors, inaccurate detection results, and inability to be widely used, and achieve simple structure, convenient detection, and low cost. Effect

Active Publication Date: 2021-02-26
SHENZHEN MERRIME NANOPORE TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is that the traditional nanopore biosensor is repeatedly used, the detection result is not accurate enough, and the operation of the disposable sensor is complicated, the cost is high, and it cannot be widely used. Nanoporous biosensor and method for making the same

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  • Disposable nanopore biosensor and manufacturing method thereof
  • Disposable nanopore biosensor and manufacturing method thereof

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Embodiment

[0031] This embodiment provides a disposable nanopore biosensor, which can be used in many application fields such as DNA sequencing, tumor marker detection, heavy metal ion detection, and chemical analysis.

[0032] The disposable nanopore biosensor such as figure 1 As shown, it includes a plastic substrate 1, a silver electrode layer 2, and a plastic top cover 3 stacked in sequence from bottom to top. The plastic top cover 3 is prepared by injection molding with a sample limiter for containing and limiting the sample to be tested. Zone 31, the sample confinement zone 31 is an open hollow position made in the top cover 3, the four walls of the hollow position confine the sample inside the sample confinement zone 31, preventing the sample from leaking out, and the center of the sample confinement zone 31 An insulating cover 32 is provided for accommodating dripped reagents. In this implementation, the insulating cover 32 is a cuboid plastic part, and the insulating cover 32 is...

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Abstract

The invention discloses a disposable nanopore biosensor, which comprises a sequentially stacked substrate, an electrode layer and a top cover, and the top cover is provided with micropores with a diameter of 5-200 μm, and the micropores are used for injecting nanopores and phospholipid films. The nanopore biosensor has a simple structure, convenient detection, and low cost. It can be added immediately at the reagent adding section to ensure the stability of the nanopore and phospholipid film itself. Mutual interference of test results among patients improves the accuracy of test results. A manufacturing method of the biosensor is also disclosed. The processing method has simple steps, is easy to operate, can be mass-produced rapidly, greatly reduces the production cost of the nanopore biosensor, and is suitable for mass industrial production and wide application.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and relates to a biosensor and a manufacturing method thereof, in particular to a disposable nanopore biosensor and a manufacturing method thereof. Background technique [0002] The high-sensitivity and high-selectivity rapid sensing analysis of biomolecules has received a lot of research and rapid development in recent years. Researchers have combined a variety of nanotechnology and used the prepared and obtained advanced nanomaterials to develop a series of electrochemical biological Sensors, among which nanopore biosensors are one of the important biological detection sensors. [0003] Nanopore generally refers to a pore structure with a pore size of 1-10nm, and its pore size is equivalent to the size of a single biological macromolecule. Usually, the nanopore is placed in an organic phospholipid film to separate the sample to be analyzed (such as serum) into two parts. When the v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 马将黄志远周智文豪
Owner SHENZHEN MERRIME NANOPORE TECH CO LTD
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