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Medicine combination containing globe artichoke extract and preparation method thereof

A technology of artichoke extract and composition, which is applied in the field of pharmaceutical composition containing artichoke extract and its preparation, and can solve problems such as discomfort reaction, poor efficacy of western medicine, and high treatment cost

Inactive Publication Date: 2018-06-15
爱可道生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing antihypertensive drugs are generally western medicines, which have relatively large side effects on the liver and kidneys of the human body and easily cause discomfort reactions such as cough, edema, dizziness, etc., and western medicines have poor efficacy, large side effects, high treatment costs, and strict requirements on diet. If you do not pay attention to diet, the therapeutic effect will not be obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] The preparation method of a pharmaceutical composition containing artichoke extract shown in the second aspect of the embodiment of the present application includes the following steps:

[0033] Put artichoke and water into the stainless steel reaction kettle according to the mass ratio of 1:4, heat to 90-95°C and turn on heat reflux, after extraction for 3 times, filter the obtained extract through a 0.45 μm filter membrane to remove impurities, collect the extract, Concentrate the extract to a liquid-to-material ratio of 1:2, add ethanol solution, and configure a solution with an ethanol concentration of 50%, and carry out alcohol precipitation after cooling for 12h to 24h, and pass the settled supernatant through a 0.45μm The filter membrane filters out impurities and collects the filtrate;

[0034] The collected filtrate is adsorbed by a resin column, and ethanol aqueous solutions with a concentration of 15%, 45%, and 95% are respectively eluted through the adsorbed...

Embodiment 1

[0040] A pharmaceutical composition containing artichoke extract, every 100 tablets of the pharmaceutical composition containing artichoke extract contains 10g of artichoke extract, filler microcrystalline cellulose 10g, mannitol 20g, disintegrant cross-linked carboxymethyl Sodium cellulose base 3g, flavoring agent stevioside 0.5g. Its preparation method is as follows:

[0041] Put the artichoke into the stainless steel reaction kettle, then add 4 times of hot water, heat to 90-95°C, turn on the heat reflux, extract 3 times, add 2 to 3 times the amount of water in the last two times, and pass the obtained extract through a 0.45 μm filter membrane Impurities were filtered out and the extract was collected. Concentrate the extract to a liquid-to-material ratio of 1:2, add ethanol solution, configure a solution with an ethanol concentration of 50%, and carry out alcohol precipitation after cooling for 24 hours, and filter the settled supernatant through a 0.45 μm filter membrane...

Embodiment 2

[0045] A pharmaceutical composition containing artichoke extract, every 100 tablets of the pharmaceutical composition containing artichoke extract contains 15g artichoke extract, filler microcrystalline cellulose 15g, mannitol 15g, disintegrant cross-linked carboxymethyl Sodium cellulose base 4g, flavoring agent stevioside 0.7g. Its preparation method is as follows:

[0046] Put the artichoke into the stainless steel reaction kettle, then add 4 times of hot water, heat to 90-95°C, turn on the heat reflux, extract 3 times, add 2 to 3 times the amount of water in the last two times, and pass the obtained extract through a 0.45 μm filter membrane Impurities were filtered out and the extract was collected. Concentrate the extract to a liquid-to-material ratio of 1:2, add ethanol solution, configure a solution with an ethanol concentration of 50%, and carry out alcohol precipitation after cooling for 24 hours, and filter the settled supernatant through a 0.45 μm filter membrane I...

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Abstract

The embodiment of the invention discloses a medicine combination containing a globe artichoke extract and a preparation method thereof. The medicine combination includes, by weight, 100-250 parts of globe artichoke extract, 30-65 parts of disintegrating agent, 150-300 parts of filling agent and 0.5-5 parts of flavoring agent. According to the preparation method, the globe artichoke extract which is extracted by means of an alcohol precipitation mode is evenly blended with the disintegrating agent, the filling agent and the flavoring agent according to a certain mass ratio and pelletized into medicine-carried particles, and the particles are tableted to obtain tablets. According to the medicine combination containing the globe artichoke extract and the preparation method thereof, the medicine combination has various healthcare effects of protecting the liver, decreasing the blood fat, reducing the blood pressure and the like and is free of side effects.

Description

technical field [0001] The present application relates to the technical field of pharmaceutical compositions, in particular to a pharmaceutical composition containing artichoke extract and a preparation method thereof. Background technique [0002] Artichoke, also known as artichoke, French lily, artichoke, artichoke, scientific name Cynara scolymus, is a perennial herb of the family Asteraceae. In European and American countries, artichoke is known as the "king of vegetables". Artichoke is rich in a variety of functional ingredients, such as cynarin, inulin, and chlorogenic acid, especially cynarin-like substances, which have significant physiological functions and can be used as raw materials for medicine and health products , It can also be used as a medicine to prevent and treat insufficient bile secretion, protect the liver, and protect the liver. [0003] Hypertension is one of the most common chronic diseases and the main risk factor for cardiovascular and cerebrovas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/20A61P1/16A61P3/06A61P9/12
CPCA61K9/20A61K36/28A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 肖立安宋阳力刘铃
Owner 爱可道生物科技有限公司
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