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A kind of spirulina biotransformation natural nano-selenium and its preparation method and application

A technology of biotransformation and nano-selenium, which is applied in the directions of medical formula, digestive system, drug combination, etc., can solve the problem of lack of radical cure and achieve the effect of reducing the residual selenium element

Active Publication Date: 2020-02-07
JINAN UNIVERSITY
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Problems solved by technology

Therefore, chronic liver disease is an inflammatory disease in essence, and there is still no cure

Method used

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  • A kind of spirulina biotransformation natural nano-selenium and its preparation method and application
  • A kind of spirulina biotransformation natural nano-selenium and its preparation method and application
  • A kind of spirulina biotransformation natural nano-selenium and its preparation method and application

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Embodiment 1

[0031] 1) Separation and preparation of spirulina biotransformation nano-selenium (BTSNP) (small test): filter and concentrate selenium-enriched spirulina to make it a high-density algae cell suspension (the preparation of the selenium-enriched spirulina is described in the literature "Enrichment of Spirulina platensis Transformation of selenium and distribution of selenium in algae. Plant Physiology Communications, 2001, 37: 12-14 "disclosed), adding sodium selenite on the basis of the original culture medium (final selenium concentration is 0.8 ± 0.1g / L) , 8000-10000lux high-light rotary culture induces 10-12h to generate a large amount of nano-red selenium. After filtration, the algal cells are resuspended in selenium-enriched medium for the second BTSNP biotransformation. A batch of high-density algal cells can be used as a bioreactor This was repeated for 5 rounds of BTSNP biotransformation. The filtrates containing BTSNP were combined, and red BTSNP was obtained after di...

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Abstract

The invention discloses spirulina biotransformed natural nano-selenium as well as a preparation method and application thereof, and belongs to the technical field of preparation of nano-selenium nutrition agents and functional food. According to the preparation method, biotransformed nano-selenium (BTSNP) is prepared from selenium-enriched spirulina through high selenium stress induction at first.Prepared red elemental selenium has a nano scale, is a spherical particle with an average particle size of 160+ / -50 nm, and has a selenium content not less than 74 percent. Animal experimental modelsfurther prove that the BTSNP has antagonism and treatment effects on arsenical toxicity-induced hepatocyte oxidation injury and hepatic fibrosis. The BTSNP is mainly applicable to auxiliary prevention and treatment of hepatitis, fatty liver and hepatic injury and other relevant diseases which are caused by various environmental pollution factors. The spirulina biotransformed natural nano-seleniumis transformed into a liver protection functional food additive or a health-care product, thereby generating a relatively large scale of social and economical benefits.

Description

technical field [0001] The invention belongs to the technical field of nano-selenium nutritional preparations and functional food preparations, and in particular relates to a new natural nano-selenium biotransformed by spirulina, a preparation method thereof and an application of antagonizing liver damage. Background technique [0002] Viral hepatitis, alcoholic hepatitis, fatty liver, liver fluke and liver damage induced by environmental pollutants are serious hazards. The abnormal structure and function of liver tissue triggered by liver cell oxidative damage and inflammatory response, as well as the secondary chronic liver fibrosis are the common pathophysiological mechanisms of all chronic liver diseases, and are the main causes of liver cirrhosis and primary liver cancer. Therefore, chronic liver disease is an inflammatory disease in essence, and there is still a lack of radical cure. Clinical treatment depends on the cause of the disease. In the acute attack stage of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/748A61P1/16A61K33/04
CPCA61K33/04A61K35/748A61K2300/00
Inventor 黄峙凌钦婕黄宏任李玉礼
Owner JINAN UNIVERSITY
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