Macromolecular hydrophilic gel and preparation method and application thereof

A polymer, water-based technology, applied in non-active ingredients medical preparations, pharmaceutical formulations, allergic diseases, etc., can solve the problems of allergies, no curative effect, limited product availability, etc., to achieve strong permeability and reduce the effect. Different, to prevent the effect of sensitization

Inactive Publication Date: 2018-06-15
XIAMEN CHUANFUTANG INDAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During use, it often happens that patients are allergic to some components of traditional Chinese medicine, and their condition sometimes goes up and down. Sometimes the gel made of Chinese medicine composition has a quick effect on some patients, but has no obvious curative effect on other patients, that is, Product has limited usability

Method used

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  • Macromolecular hydrophilic gel and preparation method and application thereof
  • Macromolecular hydrophilic gel and preparation method and application thereof
  • Macromolecular hydrophilic gel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Follow the steps below to prepare polymeric aqueous gels:

[0041] ① Weigh each raw material according to Table 1, pour carbomer, glycerin, and polysorbate into the stirring pot, start the agitator, add 80% volume of purified water, cover and stir well, and use in the next step;

[0042] ②Put the material in the previous step into the homogenizer. After homogenizing for 10 minutes, turn on the scraper agitator and the vacuum system, and the frequency of the stirring motor is 20Hz. When the vacuum in the pot reaches -0.05MPa, turn off the vacuum system and stir for 24 Obtain swelling material in hours;

[0043] ③ Dissolve NaOH and the remaining 20% ​​volume of purified water in a water pot, and heat to 80°C to obtain NaOH solution;

[0044] ④Put the swollen material obtained in step ② into the emulsification pot, heat it, and when the temperature is 80°C, turn on the homogenizer, add the NaOH solution obtained in step ③ into the emulsification pot, homogenize for 5 minu...

Embodiment 2

[0054] The amount of raw materials is shown in Table 1, and the preparation method is the same as in Implementation 1. The obtained product is tasteless, non-irritating, transparent, has irregular bubbles, and has no other visible foreign impurities. It is a viscous colloid, no peculiar smell, and pH=6.8 , the dynamic viscosity is 6064mPa.s, and the microbial content is 10cfu / g, which meets the requirements for use. In clinical trials, the polymer water-based gel obtained in this embodiment has a total effective rate of 86.11% for patients with allergic rhinitis, while the same kind listed in the control group The effective rate of the product Mobijing is 66.6%, which shows that the polymer water-based gel of the present invention is superior to other similar products in treating allergic rhinitis, and has good preventive and auxiliary therapeutic effects on allergic rhinitis.

Embodiment 3

[0056] The amount of raw materials is shown in Table 1. The preparation method is the same as in Implementation 1. The obtained product is tasteless, non-irritating, transparent, has irregular bubbles, and has no other visible foreign impurities. It is viscous colloid, has no peculiar smell, and has a pH of 7.2 , the dynamic viscosity is 6462mPa.s, and the microbial content is 10cfu / g, which meets the requirements for use. In clinical trials, the total effective rate of the polymer water-based gel obtained in this embodiment can reach about 90% for patients with allergic rhinitis, while the control group The effective rate of Mobijing of the listed similar products is not more than 70%, which shows that the polymer water-based gel of the present invention is better than other similar products in the treatment of allergic rhinitis, and has better preventive and auxiliary therapeutic effects on allergic rhinitis .

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Abstract

The invention relates to a macromolecular hydrophilic gel and a preparation method and application thereof. The gel is made of Carbomer mixed with purified water, glycerinum and polysorbate, the pH value is adjusted by using sodium hydroxide solution, and the gel with negative electricity is prepared. The macromolecular hydrophilic gel has irregular bubbles, no stimulation and no other macroscopicexogenous impurities, and is transparent, in a viscous colloid shape and free from extraneous odor, the pH value is equal to 6.30-9.37, the dynamic viscosity is 5000-7000 mPa s, the microbial contentis 10 cfu / g, the total effective rate for allergic rhinitis patients in a clinical test can reach about 90%, and the effective rate of an on-sale congeneric product Mobijing as a control group is nomore than 70%; it is shown that compared with the congeneric product, the macromolecular hydrophilic gel can cure allergic rhinitis better, and has a good preventive and adjuvant therapeutic effects on the allergic rhinitis.

Description

technical field [0001] The invention relates to the field of water-based gels, in particular to a polymer water-based gel and its preparation method and application. Background technique [0002] Allergic rhinitis (AR), also known as allergic rhinitis, refers to the production of immunoglobulin E (IgE) after the nasal mucosa is exposed to allergens such as dust mite or house dust mite, which is adsorbed on the surface of basophilic cells, causing Body sensitization. When exposed to the same allergen again, the allergen combines with IgE, activates the enzymes in the basophilic cells, releases mediators such as histamine and slow-reacting substances, and manifests as pale nasal mucosa, edema, and a large amount of clear nasal discharge in the nose , nasal itching, sneezing, runny nose and other clinical symptoms. For the treatment of allergic rhinitis, the main methods are to get rid of allergen drugs, specific immunotherapy and other therapies. [0003] Chinese invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/32A61K47/26A61K47/10A61K47/02A61P37/08A61P11/02
CPCA61K9/0043A61K9/06A61K47/02A61K47/10A61K47/26A61K47/32
Inventor 邱斌杰许明塔
Owner XIAMEN CHUANFUTANG INDAL
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