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Bone implant material as well as preparation method and application thereof

A technology of bone implant material and polymer material, applied in the field of bone implant material and its preparation, can solve problems such as insufficient bone activity, and achieve the effect of improving efficiency and enhancing curative effect

Active Publication Date: 2018-05-25
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] At present, the commonly used degradable polymer bone implant materials are mostly inert materials, and the lack of bone activity is the key factor restricting their application.

Method used

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  • Bone implant material as well as preparation method and application thereof
  • Bone implant material as well as preparation method and application thereof
  • Bone implant material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] This embodiment provides a method for preparing a bone implant material BP@PLGA film, which includes the following steps:

[0067] Step 1, first prepare two-dimensional layered black phosphorus: weigh block black phosphorus in a mortar, gradually add N-methylpyrrolidone, the dosage ratio of block black phosphorus and N-methylpyrrolidone is 1mg: 1mL , after grinding sufficiently, perform ultrasonication in an ice-water bath, after ultrasonication for 6 hours, centrifuge at a speed of 4000rpm for 15min, take the supernatant, and obtain a suspension of two-dimensional layered black phosphorus; put the suspension of two-dimensional layered black phosphorus at 12000rpm Speed ​​centrifugation for 15 minutes and take the precipitate to obtain two-dimensional layered black phosphorus;

[0068] The two-dimensional layered black phosphorus is ultrasonically dispersed in a small amount of absolute ethanol, the amount of absolute ethanol can cover the two-dimensional layered black ...

Embodiment 2 Embodiment 1

[0072] Example 2 Degradation experiment of bone implant material BP@PLGA film in Example 1

[0073] The degradation experiment was carried out using the bone implant material BP@PLGA film prepared in Example 1. The BP@PLGA film was taken as the research object of degradation, and samples were taken every week for weight loss measurement, and the samples were photographed and observed every two weeks. The results were as follows: figure 1 , figure 2 and image 3 as shown, figure 1 It is the comparison chart of weight loss test of BP@PLGA film and PLGA degradation experiment in this embodiment; figure 2 It is the comparison curve of "degradation time-mass retention rate" in the degradation experiment of BP@PLGA film and PLGA in this embodiment; image 3 It is the "degradation time-phosphate ion concentration" curve of black phosphorus in the BP@PLGA film of this example.

[0074] likefigure 1 As shown, local rupture and blistering of the film can be observed from the four...

Embodiment 3

[0079] Example 3 Near-infrared laser-assisted experiment of BP@PLGA film promoting new bone formation in Example 1

[0080] The bone implant material BP@PLGA film prepared in Example 1 was used to conduct near-infrared laser-assisted promotion of new bone formation experiments.

[0081] The best conditions for promoting bone formation in this embodiment are: 808nm near-infrared laser irradiation to raise the temperature to 40.5±0.5°C, and keep the temperature for 1 minute, and then cool down naturally. The treatment cycle was 4 days / time, lasting 3 weeks. The expression of stem cell osteogenesis-related proteins, such as osteocalcin (OCN) and osteopontin (osteopontin, OPN), were measured at 7 days, 14 days and 21 days respectively, and the results were as follows: Figure 4 and Figure 5 shown. Figure 4 Schematic diagram of the expression of osteocalcin in the BP@PLGA film that promotes osteogenesis under near-infrared laser stimulation; Figure 5 Schematic diagram of the...

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Abstract

The invention provides a bone implant material as well as a preparation method and application thereof. The preparation method of the bone implant material comprises the following steps: carrying outultrasonic dispersion on black phosphorus and dissolving into a first solvent to obtain dispersion liquid A; dissolving a high polymer material into a second solvent to obtain a solution B; mixing thedispersion liquid A with the solution B and carrying out ultrasonic treatment to obtain a solution of a uniformly-dispersed BP@ high polymer material; injecting the solution into a mold for molding or carrying out three-dimensional printing and molding, and volatilizing the solvent to obtain the bone implant material. The bone implant material has photothermal osteogenesis promoting function andcan be degraded in the physiological environment; when the bone implant material as an implant for a bone defect filling part is applied to clinical treatment of bone defect, the efficiency of promoting osteogenesis with heat by penetrating through biological tissues through near infrared can be improved; besides, the bone implant material also can be combined with clinical physiotherapy so as tobetter promote the healing effect of the bone defect; meanwhile, a biodegradable product of the bone implant material is essential for a human body and can participate in bone healing and regenerationprocess.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and relates to a bone implant material and its preparation method and application. Background technique [0002] With the arrival of the aging population in our society, the number of bone trauma or bone tumors has increased significantly. Clinically, the cases of bone defects caused by bone trauma and bone tumors, fractures and nonunions at difficult-to-heal sites are increasing year by year, and the treatment is difficult. [0003] There are many factors that cause bone defects, common ones are fractures, external trauma (such as car accidents, wars, accidental injuries, etc.) and bone tumor surgery. Among them, fractures caused by bone loss in the elderly and bone defects caused by external trauma account for more than 75% of the total factors. Population aging is a common problem in both developed and developing countries. As early as 1999, my country entered the aging ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/58A61L27/54A61L27/50A61K41/00
CPCA61K41/0052A61L27/12A61L27/18A61L27/50A61L27/54A61L27/58A61L2300/112A61L2430/02C08L67/04
Inventor 童丽萍喻学锋王怀雨
Owner SHENZHEN INST OF ADVANCED TECH
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