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Gene for screening acute myocardial infarction complicated by cardiac rupture and expression product thereof

A technology for acute myocardial infarction and cardiac rupture, applied in the fields of biochemistry and molecular biology, can solve the problems of elevated methylation level in the promoter region of PF4 gene and no PF4 gene, and achieve important clinical application significance and development. Value, scientific and reasonable structure, safe and convenient use

Pending Publication Date: 2018-05-22
聂绍平
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Problems solved by technology

Among them, the methylation level of the promoter region of the PF4 gene was significantly increased, and there was no report on the relationship between the PF4 gene and cardiac rupture in the existing studies

Method used

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  • Gene for screening acute myocardial infarction complicated by cardiac rupture and expression product thereof

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[0021] 1. Collection of cases: 20 patients each with acute myocardial infarction complicated with cardiac rupture and acute myocardial infarction without cardiac rupture were selected.

[0022] (1) Diagnostic criteria for acute myocardial infarction:

[0023] Myocardial injury markers are elevated, and there is at least one of the following evidences of myocardial ischemia:

[0024] ①Typical symptoms of myocardial ischemia

[0025] ② ECG changes suggest new ischemia

[0026] ③ New pathological Q wave in ECG

[0027] ④ Imaging examinations suggest new loss of viable myocardium or abnormal regional wall motion

[0028] (2) Diagnostic criteria for cardiac rupture;

[0029] Cardiac rupture can be diagnosed when at least one of the following items is met:

[0030] ① Surgically confirmed cardiac rupture

[0031] ② No history of heart failure, cardiac arrest caused by electromechanical dissection, and pericardial hematoma confirmed by echocardiography

[0032] ③ Sustained hypo...

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Abstract

The invention discloses a gene for screening acute myocardial infarction complicated by cardiac rupture and an expression product thereof, which are characterized by application of the platelet factor4(PF4) gene and the expression product thereof to the preparation of an acute myocardial infarction risk prediction marker and a diagnostic preparation. The acute myocardial infarction risk prediction marker and the diagnostic preparation adopt conventional PCR (Polymerase Chain Reaction) relative quantification, a fluorescent quantification kit, protein hybridization, an enzyme-linked immunoassay method and a gene chip to assay the expression level of gene in the peripheral blood of a subject or a patient with acute myocardial infarction. The invention provides the application of the PF4 gene and / or the expression product of the gene as a novel marker for screening acute myocardial infarction complicated by cardiac rupture, provides a novel method for predicting and diagnosing the risk of acute myocardial infarction complicated by cardiac rupture by means of the PF4 gene or the expression product of the gene and utilizes the PF4 gene and the expression product thereof to prepare themarker for predicting the risk of acute myocardial infarction complicated by cardiac rupture and the diagnostic preparation for the first time.

Description

technical field [0001] The invention belongs to the technical field of biochemistry and molecular biology, and specifically relates to a gene and its expression product for screening acute myocardial infarction combined with cardiac rupture. Background technique [0002] With the development of society and economy, the improvement of living standards and the aging population, the incidence and mortality of acute myocardial infarction are increasing year by year. WHO predicts that by 2030, the death caused by acute myocardial infarction will account for 13.4% of the total death, which is the main cause of death in the world. Cause of death: Cardiac rupture is a serious fatal complication of acute myocardial infarction, with a mortality rate of over 75%. However, cardiac rupture often occurs suddenly and often manifests as sudden death, so clinical trials related to it are extremely difficult. Currently, methods for the prediction and diagnosis of CR are lacking. How to diag...

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/6851
CPCC12Q1/6851C12Q1/6883C12Q2600/154
Inventor 聂绍平公威
Owner 聂绍平
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