Method for extracting astaxanthin in haematococcus pluvialis through continuous phase transition

A technology of Haematococcus pluvialis and astaxanthin, which is applied in solid solvent extraction, organic chemistry and other directions, can solve problems such as being unsuitable for large-scale continuous production, low extraction rate of natural astaxanthin, and unsuitable for industrial production, etc. The effect of shortening extraction and separation time, shortening extraction time, reducing solvent consumption and energy consumption

Inactive Publication Date: 2018-05-18
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Astaxanthin and its extracts from natural algal sources have been widely used in developed countries such as Europe, America, Japan, and Southeast Asia, but astaxanthin is sensitive to light, heat, and oxygen, and the thick-walled characteristics of Haematococcus pluvialis have caused The extraction rate of natural astaxanthin is low, the annual output is small, and the price is expensive
The patent (Lu Zhe, CN106467479A) adopts physical wall breaking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: A method for continuous phase change extraction of astaxanthin in Haematococcus pluvialis, comprising the following steps:

[0020] (1) The selected high-quality Haematococcus pluvialis after removing impurities is dried at 40°C, the water content is controlled at 15%, and crushed to 60 mesh to obtain the raw material of Haematococcus pluvialis.

[0021] (2) Weigh 10kg of the treated Haematococcus pluvialis raw material, put it into the extraction kettle of the continuous phase change extraction device, feed 90L of liquefied petroleum gas, and under the conditions of extraction temperature 30°C and extraction pressure 0.1Mpa, Flow through the extraction kettle at a flow rate of 450L / h, and continuously extract for 150min. After extracting astaxanthin from Haematococcus pluvialis, it flows into the desorption kettle. The desorption temperature is 80°C, and the desorption pressure is 0.2Mpa. The liquefied petroleum gas is changed into a gas, and then compres...

Embodiment 2

[0023] Embodiment 2: A method for continuous phase change extraction of astaxanthin in Haematococcus pluvialis, comprising the following steps:

[0024] (1) Select high-quality Haematococcus pluvialis after removing impurities, dry it at 45°C, control the moisture content at 10%, and crush it to 40 mesh to obtain the raw material of Haematococcus pluvialis.

[0025] (2) Weigh 10kg of the treated Haematococcus pluvialis raw material, put it into the extraction kettle of the continuous phase change extraction device, and feed 90L of liquefied petroleum gas, under the conditions of extraction temperature 50°C and extraction pressure 0.3Mpa, Flow through the extraction kettle at a flow rate of 400L / h, and extract continuously for 150min. After extracting astaxanthin from Haematococcus pluvialis, it flows into the desorption kettle. The desorption temperature is 85°C and the desorption pressure is 0.1Mpa. The liquefied petroleum gas is changed into a gas, and then compressed into a...

Embodiment 3

[0026] Embodiment 3: A method for continuous phase change extraction of astaxanthin in Haematococcus pluvialis, comprising the following steps:

[0027] (1) The selected high-quality Haematococcus pluvialis after removing impurities is dried at 50°C, the moisture content is controlled at 13%, and crushed to 40 mesh to obtain the raw material of Haematococcus pluvialis.

[0028] (2) Weigh 10kg of the treated Haematococcus pluvialis raw material, put it into the extraction kettle of the continuous phase change extraction device, feed 100L of liquefied petroleum gas, and under the conditions of extraction temperature of 50°C and extraction pressure of 0.6Mpa, Flow through the extraction kettle at a flow rate of 120L / h, and continuously extract for 180min. After extracting astaxanthin from Haematococcus pluvialis, it flows into the desorption kettle, the desorption temperature is 80°C, and the desorption pressure is 0.3Mpa. Make the different liquefied petroleum gas phase into gas...

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PUM

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Abstract

The invention provides a method for extracting astaxanthin in haematococcus pluvialis through continuous phase transition. A continuous phase transition extraction process is adopted, liquefied petroleum gas is adopted as an extracting agent, the material-liquid ratio, namely the ratio of the haematococcus pluvialis raw material to the liquefied petroleum gas is 10 g:(80-100) ml, the extraction temperature ranges from 35 DEG C to 45 DEG C, the pressure ranges from 0.1 Mpa to 0.5 Mpa, the flow rate of the extracting agent ranges from 400 L/h to 500 L/h, the continuous extraction time ranges from 120 min to 150 min, the resolving temperature ranges from 80 DEG C to 90 DEG C, and the resolving pressure ranges from 0.1 Mpa to 0.2 Mpa. The extraction time can be shortened, the production cost of the astaxanthin is effectively reduced, the technological process is simple, high operability is achieved, the extraction efficiency is high, the content of the astaxanthin is high, and the method is environmentally friendly, free of pollution, good in completeness and repeatibility and capable of being industrially and continuously produced on a large scale.

Description

technical field [0001] The invention belongs to the technical field of extracting carotenoids from microalgae, in particular to a method for extracting astaxanthin from Haematococcus pluvialis. Background technique [0002] Astaxanthin (3,3′-dihydroxy-4,4′-diketo-β,β′-carotene, C 40 h 52 o 4 ) is a terpene unsaturated compound. Natural astaxanthin is one of the strongest natural antioxidants in the world. It is the only carotenoid that can pass through the blood-brain barrier. Astaxanthin is harmful to the brain, central nervous system and eyes. can play a protective role. Harvard researcher Preston Mason said that astaxanthin has great potential to become a new type of antioxidant and anti-inflammatory agent, and it is expected to set off the third wave of preventive drugs after statins and antiplatelet drugs. [0003] Haematococcus pluvialis is a ubiquitous green algae and another economic microalgae after spirulina and salina. Haematococcus pluvialis is the main sour...

Claims

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Application Information

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IPC IPC(8): C07C403/24B01D11/02
CPCC07C403/24B01D11/02
Inventor 曹庸刘飞李敏雄郭斌
Owner SOUTH CHINA AGRI UNIV
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