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A method for extracting solanesol

A technology for solanesol and extraction solvent, applied in the field of extraction of solanesol, can solve the problems of numerous extraction process flow, large scale production difficulty, low product extraction rate, etc., achieve high product purity, improve comprehensive utilization rate, reduce The effect of chemical preparation process

Active Publication Date: 2021-01-15
GUANGDONG BRANCH OF CHINA TOBACCO GENERAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Two, the extraction rate of the product is low and the yield is low, and the product purity is not high simultaneously;
[0008] 3. There are many extraction processes and large-scale production is difficult
At present, there is no report on the application of silver ion complex extraction method to extract solanesol from tobacco

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048]Collect discarded tobacco leaves, remove moldy tobacco leaves and impurities, add tobacco leaves and water according to the weight ratio of tobacco leaf: water = 1:10, soak for 2 hours at a temperature of 40°C, filter, and wash the filter residue with water several times until the filtrate is colorless. The filter residue is collected and baked in an oven at a temperature of 80°C for 4 hours. The filter residue is crushed to obtain coarse tobacco leaf powder of 20-40 mesh.

[0049]Take 10g of the tobacco leaves obtained above, add 100ml of ammonia water with a concentration of 15%, seal and place in a 40°C water bath for heating for 2 hours, then filter under reduced pressure, discard the filtrate, and retain the filter residue.

[0050]Add 150ml of extraction solvent composed of 95% methanol and n-hexane (volume ratio 40:60) to the above filter residue, the ratio of filter residue to extraction solvent (weight: volume) is 1:10, reflux and stir for 3 hours, cool and filter, The filt...

Embodiment 2

[0055]Collect discarded tobacco leaves, remove moldy tobacco leaves and impurities, add tobacco leaves and water according to the weight ratio of tobacco leaf: water = 1:20, soak for 2 hours at a temperature of 60°C, filter, and wash the filter residue with water several times until the filtrate is colorless. The filter residue is collected and baked in an oven at a temperature of 60°C for 4 hours. The filter residue is pulverized to obtain coarse tobacco leaf powder of 20-40 mesh.

[0056]Take 10g of the tobacco leaf obtained above, add 100ml of ammonia water with a concentration of 10%, seal it and place it in a 60°C water bath, heat for 2 hours, then filter under reduced pressure, discard the filtrate, and retain the filter residue.

[0057]Add 150ml of extraction solvent composed of 95% methanol and n-hexane to the above filter residue, the volume ratio of the two is 50:50, the ratio of filter residue to extraction solvent is 1:20, reflux and stir for 5 hours, cool and filter to obtai...

Embodiment 3

[0062]Collect discarded tobacco leaves, remove moldy tobacco leaves and impurities, add tobacco leaves and water according to the weight ratio of tobacco leaf: water = 1:8, soak for 2 hours at a temperature of 40°C, filter, and wash the filter residue with water several times until the filtrate is colorless. The filter residue is collected and baked in an oven at a temperature of 80°C for 4 hours. The filter residue is crushed to obtain coarse tobacco leaf powder of 20-40 mesh.

[0063]Take 10g of the tobacco leaves obtained above, add 100ml of ammonia water with a concentration of 20%, seal and place in a 60°C water bath, heat for 2 hours, then filter under reduced pressure, discard the filtrate, and retain the filter residue.

[0064]Add 150ml of extraction solvent composed of 95% methanol and n-hexane to the above filter residue, the mixing volume ratio is 50:50, the ratio of filter residue to extraction solvent (weight: volume) is 1:10, reflux and stir for 3 hours, cool and filter, Th...

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Abstract

The invention relates to a method for highly selectively extracting solanesol. The method comprises the following specific processes: soaking and boiling tobacco leaves with deionized water, filtering, baking filtered residue, and crushing to obtain coarse tobacco leaf powder; adding ammonia water into the coarse tobacco leaf powder, performing ammonolysis, and extracting to obtain paste; adding ethyl alcohol into the paste, extracting to obtain a coarse product, and performing post-processing to obtain coarse solanesol; after the coarse solanesol is dissolved, complexing with metal ions in ametal ion aqueous solution to obtain precipitate; and drying the precipitate under reduced pressure, adding a mixed solution of n-hexane and water, oscillating in water bath, separating liquid to obtain an upper organic phase, and drying to obtain white solid, namely, the solanesol, under the reduced pressure. Compared with the conventional process, repeated column chromatography elution is not required to be performed with a large number of organic solvents by the method provided by the invention; high-purity solanesol is obtained by selectively complexing with the solanesol by utilizing silver ions; the process is simple; the product purity is high; the cost is low; and the energy consumption is low.

Description

Technical field[0001]The invention relates to a method for extracting solanesol, belonging to the technical field of separation and purification of plant effective ingredients.Background technique[0002]Solanesol is an unsaturated polyisoprene alcohol. Because it contains multiple non-conjugated double bonds in the molecule, it has a very strong ability to absorb free radicals. It has antibacterial, anti-inflammatory and hemostatic effects, which is important Pharmaceutical intermediates are irreplaceable components of ubiquinone drug intermediates. They are synthetic vitamin K side chains and coenzyme Q10, as well as synthetic anti-ulcer drugs and anti-cancer drugs. They are irreplaceable natural raw materials. It is also synthetic vitamin K2 and anti-cancer drugs. , Anti-ulcer drugs, cardiovascular disease and anti-aging drugs Coenzyme Q10 raw materials, especially as the main raw material for the production of Coenzyme Q10. Coenzyme Q10 is most commonly used in medicine for the pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C29/74C07C33/02
CPCC07C29/74C07C33/02
Inventor 陈桢禄郑荣豪颜文忠李正勇陈泽鹏
Owner GUANGDONG BRANCH OF CHINA TOBACCO GENERAL
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