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Preparation method of red tangerine peel capsules

A technology of capsules and orange reds, which is applied in the field of preparation of traditional Chinese medicine capsule preparations, can solve the problems of poor particle fluidity, uncontrollable thickness ratio, and uneven particle size distribution, so as to achieve convenient and smooth swallowing, easy control of the filling process, and granule good fluidity

Inactive Publication Date: 2018-05-18
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The original Juhong Capsules are granulated by conventional wet method, the prepared granules are irregular, the particle size distribution is uneven, the thickness ratio is uncontrollable, the granule fluidity is not good, the granule gap is large, and the bulk density is small. After many improvement tests, the drug The maximum bulk density can only reach about 0.88g / ml, and the weight of the particles filled into the No. 1 capsule shell is less than 0.44g. Therefore, it is very difficult to change the No. 0 empty capsule to the No. 1 filling of the orange red capsule.

Method used

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  • Preparation method of red tangerine peel capsules
  • Preparation method of red tangerine peel capsules

Examples

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Embodiment 1

[0039] A preparation method for Juhong capsules, comprising the following steps:

[0040] (1) 460 grams of orange red dry paste powder, 5 grams of starch, and 30 grams of calcium phosphate are placed in a wet mixing granulator and mixed evenly, and then 30 grams of 80% ethanol solution containing 1% of HPMC and 3% of K30 are added, well mixed;

[0041] (2) Go in the dry granulator, adjust the feed screw speed 16r / min, roll pressure 270KN, pinch wheel speed 10r / min, control the material sheet thickness 1 ~ 2 mm, and its material moisture content is 3.5%;

[0042] (3) Extrude the sheet material into granules, add 1 gram of magnesium stearate and 4 grams of silicon dioxide, mix, pack into No. 1 capsules at 0.5 g / capsule, and obtain 1000 capsules.

Embodiment 2

[0044] A preparation method for Juhong capsules, comprising the following steps:

[0045] (1) Put 460 grams of orange red dry paste powder, 3 grams of starch, and 32 grams of calcium phosphate into a wet mixing granulator and mix evenly, then add 35 grams of 80% ethanol solution containing 3% HPMC and 1% K30, well mixed;

[0046] (2) transfer to the dry granulator, adjust the feeding screw speed 20r / min, roll pressure 260KN, pinch wheel speed 18r / min, control the material sheet thickness 1 ~ 2 mm, and its material moisture content is 4.5%;

[0047] (3) Extrude the sheet material into granules, add 1 gram of magnesium stearate and 4 grams of silicon dioxide, mix, pack into No. 1 capsules at 0.5 g / capsule, and obtain 1000 capsules.

Embodiment 3

[0049] A preparation method for Juhong capsules, comprising the following steps:

[0050] (1) Put 460 grams of orange red dry paste powder, 4 grams of starch, and 31 grams of calcium phosphate into a wet mixing granulator and mix evenly, then add 32 grams of 80% ethanol solution containing 2% HPMC and 2% K30, well mixed;

[0051] (2) transfer in the dry granulator, adjust feeding screw speed 18r / min, roll pressure 270KN, pinch wheel speed 15r / min, control material piece thickness 1~2 millimeter, its material water content is 4%;

[0052] (3) Extrude the sheet material into granules, add 1 gram of magnesium stearate and 5 grams of silicon dioxide, mix, pack into No. 1 capsules at 0.5 g / capsule, and obtain 1000 capsules.

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Abstract

The invention provides a preparation method of a traditional Chinese medicine capsule preparation, and particularly relates to a preparation method of red tangerine peel capsules. The method includesthe steps that red tangerine peel dry extract powder, starch and calcium phosphate are mixed, an ethanol solution containing hydroxypropyl methylcellulose and povidone is added, dry granulating is performed under the condition that the moisture content of the materials is 3.5-4.5%, and finally the density of medicinal powder reaches 1.00 g / ml or above to meet the filling requirements of No.1 capsules. Thus, smooth filling of the capsules is guranateed, medicine quality is guranateed at the same time, clinically, elderly patients or child patients or other patients with pharyngeal diseases canconveniently swallow the medicine, and the patients can well follow the doctor's advice on medication.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine capsule preparation, in particular to a preparation method of Juhong capsule. Background technique [0002] Capsules are preparations that are filled with drugs in a hollow capsule shell that is tightly fitted by the capsule body and capsule cap. According to the capsule drug standard, hollow capsules have 8 sizes and specifications code-named No. 000, No. 00, No. 0, and No. 1 to No. 5, all of which are cylindrical. Among them, the specifications and volume of capsules from No. 00 to No. 2 are: No. 00, the volume is 0.95ml; No. 0, the volume is 0.68ml; No. 1, the volume is 0.50ml; No. 2, the volume is 0.37ml. That is, the larger the number of specifications, the smaller the volume of the bag body, that is, the less weight of the contents. [0003] The appropriate filling volume of No. 0 capsule is generally between 0.4 and 0.6 g, and the filling volume of No. 1 capsule is...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/48A61K47/02A61K47/04A61K47/12A61K47/38A61K47/32
CPCA61K9/1611A61K9/1617A61K9/1635A61K9/1652A61K9/1682A61K36/752
Inventor 卿光明余定祥刘云龙钟瑛
Owner SICHUAN MEDCO PHARML
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