A kind of preparation method of Yigan Shukang Capsule

A technology of Yigan Shukang and capsules, which is applied in the field of preparation of Chinese patent medicines, can solve the problems of inability to ensure sufficient extraction of active ingredients and low transfer rate

Active Publication Date: 2021-04-20
SHAANXI DONGKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Aiming at the problems existing in the prior art, the object of the present invention is to provide a preparation method of Yigan Shukang Capsules, which solves the problem that the existing extraction process cannot ensure the sufficient extraction of active ingredients so that the transfer rate is low

Method used

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  • A kind of preparation method of Yigan Shukang Capsule
  • A kind of preparation method of Yigan Shukang Capsule
  • A kind of preparation method of Yigan Shukang Capsule

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preparation example Construction

[0087] The raw materials for preparing Yigan Shukang Capsules are: 10-15 parts by mass of Phyllostachys phylloxera, 15-20 parts by mass of Salvia Miltiorrhiza, 15-20 parts by mass of Hedyotis diffusa, 15-20 parts by mass of Astragalus, 15-20 parts by mass of Polygonum multiflorum, Polygonum cuspidatum 15-20 parts by mass, the sum of the parts by mass of raw materials is 100 parts. Its preparation method comprises the following steps:

[0088] Step 1: take Astragalus membranaceus, decoct and extract twice, combine the extracts, filter, and use the dregs for later use, concentrate the filtrate under reduced pressure to a thick paste, and dry it in vacuum to form a fine powder A;

[0089] Step 2: Add the dregs of Step 1 to the herbs of Phyllostachys phylloxera, Salvia, Hedyotis diffusa, Polygonum cuspidatum and Polygonum multiflorum, extract twice with ethanol under reflux, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure and concentr...

Embodiment

[0098] The components of Yigan Shukang Capsules in this example are: Phyllostachys foliage 322g, Salvia miltiorrhiza 600g, Hedyotis diffusa 460g, Radix Astragali 460g, Polygonum multiflorum 460g, Polygonum cuspidatum 460g; After purification, they are divided into two groups, which specifically include the following steps:

[0099] Step 1: Take Radix Astragalus and extract twice, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, each time for 2 hours, combine the two extracts, filter, and set aside the dregs, the filtrate is at -0.04 Mpa, concentrated under reduced pressure at 70°C to a thick paste with a relative density of 1.35-1.45 (60°C), dried in vacuum to fine powder A;

[0100] Step 2: Add the dregs of step 1 to the medicinal materials of Phyllostachys phylloxera, Danshen, Hedyotis diffusa, Polygonum cuspidatum and Polygonum multiflorum, add 70% ethanol to reflux and extract twice, add 12 times the amount for the f...

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Abstract

The invention discloses a preparation method of Yigan Shukang Capsules. Firstly, astragalus is extracted with water, the extract is concentrated and dried into fine powder A, and the dregs are combined with phylloxera, salvia miltiorrhiza, hedyotis diffusa, polygonum cuspidatum and fleece-flower root, and 70% Extract with ethanol, concentrate and dry the extract into fine powder B, mix fine powder A and fine powder B evenly, granulate in one step, and pack into capsules to obtain Yigan Shukang Capsules. The present invention adopts group extraction, which can enrich the active ingredients, thereby improving the curative effect of the product and reducing the dosage. Compared with the original process group, the Yigan Shukang Capsules prepared by the method of the present invention can reduce the dosage by 20%. The effect of inhibiting the expression of HBsAg and HBeAg in HepG2-2.2.15 cells and the protective effect on chronic liver injury (CCl4 model) are still stronger than the original process.

Description

technical field [0001] The invention belongs to the technical field of preparation of Chinese patent medicines, and in particular relates to a preparation method of Yigan Shukang capsules. Background technique [0002] Hepatitis B is a globally recognized major public health problem, which not only seriously affects health but also imposes a heavy burden on individuals and families. It is an infectious disease caused by hepatitis B virus (Hepatitis B virus, HBV), mainly characterized by hepatitis and may cause damage to multiple organs. According to the World Health Organization (WHO) report, there are about 2 billion people who have been infected with HBV in the world, of which 350 million are chronically infected with HBV. There are about 1 million people with hepatocellular carcinoma (Hepatocellular Carcinoma, HCC). There are about 120 million chronic hepatitis B virus carriers in my country, which is the country with the largest number of carriers. Among them, there are ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/748A61P1/16A61P31/20
CPCA61K9/1682A61K36/47A61K36/481A61K36/537A61K36/704A61K36/748A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 夏传涛杜杉王芳
Owner SHAANXI DONGKE PHARMA
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