Carboxymethyl chitosan nano microsphere loaded with photodynamic antibiotic and synthesis method of nano microsphere

Abstract

The invention relates to a carboxymethyl chitosan nano microsphere loaded with a photodynamic antibiotic and a synthesis method of the nano microsphere. The PH responsive nano microsphere is synthesized; the nano microsphere is hydrolyzed under an acidic condition, and immediately releases much photosensitizer to achieve a rapid and effective antibiotic effect; under a neutral or alkaline condition, the nano microsphere performs slow release, and can perform long-acting antibiosis for a week; the synthesis method is simple; a main raw material of carboxymethyl chitosan is an excellent biocompatible material; a cross-linking agent utilized is low in toxicity; a synthesis process of the nano microsphere is simple and convenient; organic reagents used are fewer; main materials are good in biocompatibility; the nano microsphere has small influence on a normal structure after the nano microsphere enters a human body; and the nano microsphere has an obvious destruction and killing effects ona bacterial biofilm and an obvious effect on drug-resistance bacteria, and can be effectively applied to in-vivo antibiosis and anti-biofilm treatment.

Description

technical field [0001] The invention specifically relates to the technical field of new materials, in particular to a carboxymethyl chitosan nanometer microsphere loaded with photodynamic bactericidal drugs and a synthesis method thereof. Background technique [0002] Bacterial infection is an important cause of human diseases, such as respiratory system diseases and reproductive system diseases are mostly caused by bacterial infection. Bacterial infections can also cause strokes and worsen other medical conditions. Various clinical traumatic operations in the hospital, such as surgical biopsy, built-in catheters (such as urinary catheters, intravenous catheters) will destroy the integrity of the skin, which can lead to the invasion of pathogens, as we know, the most important and effective treatment for bacterial infections is the use of antibiotics . In addition bacteria can form biofilms in different implants, most commonly orthopedic implants and indwelling catheters. ...

AI Technical Summary

Problems solved by technology

Including the number of layers through self-assembly technology, the synthesis of intelligent multi-layer film, so that it has temperature responsiveness or responsiveness, micro-environmental responsiveness and antibacterial adhesion function, showing excellent long-term antibacterial effect, but it cannot prevent drug-resistant bacteria at all production