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Monochloro substitution second type halogenated polyketone compound, and preparation method and application thereof

A polyketide compound, chlorine substitution technology, applied in the field of microorganisms, can solve problems such as no medicine

Active Publication Date: 2018-05-11
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the abuse of antibiotics, the emergence of many "super bacteria" has brought huge challenges to the clinical treatment of diseases such as pathogenic bacterial infections, and some super bacteria have no cure.

Method used

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  • Monochloro substitution second type halogenated polyketone compound, and preparation method and application thereof
  • Monochloro substitution second type halogenated polyketone compound, and preparation method and application thereof
  • Monochloro substitution second type halogenated polyketone compound, and preparation method and application thereof

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Experimental program
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Embodiment Construction

[0039] The present invention will be further described in detail below through specific implementations:

[0040] 1. Activation of Streptomyces sp. FJS31-2 strain

[0041] Take out the spores of Streptomyces sp. FJS31-2 from the refrigerator at -80℃, dig out 1 spores of Streptomyces sp.FJS31-2 with a sterile inoculation loop, and inoculate the spores on a basal medium plate with a diameter of 11cm with a cross-hatch. Place the culture for 3 days, pick a single colony and pass it to the third generation for amplification.

[0042] 2. Enrichment of fermentation products

[0043] The modified GYD solid medium was selected for fermentation and culture. Agar powder was added to the medium, and the culture medium was kept standing at 28°C for 17 days. The bacteria and the medium were mashed and extracted twice with ethyl acetate. The extracts were combined and concentrated under reduced pressure to obtain fermentation. product.

[0044] 3. Purification and separation of fermentation product...

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Abstract

The invention discloses a monochloro substitution second type halogenated polyketone compound. The structural formula of the monochloro substitution second type halogenated polyketone compound is as shown in the description. The compound has antibacterial activity against Gram-positive bacteria, Gram-negative bacteria or fungi. More monochloro compounds are obtained by improving a preparation method, meanwhile the antibacterial activity of the compound is screened, and results show that the compound has spectrum antibacterial activity and has the antibacterial activity against the Gram-positive bacteria such as Staphylococcus aureus (MRSA) and drug-resistance bacteria, staphylococcus epidermidis and bacillus subtilis thereof; the compound has the antibacterial activity against the Gram-negative bacteria such as escherichia coli (ESBL) capable of producing hyper spectrum beta-lactamase, proteusbacillus vulgaris and bacterium burgeri; the compound has the antibacterial activity against the fungi such as Candida albicans.

Description

Technical field [0001] The present invention relates to the technical field of microorganisms, in particular to a type II halogenated polyketone compound substituted with monochlorine and a preparation method and application thereof, and in particular to a type II halogenated polyketone compound zunyimycin D which is substituted with monochlorine and its application. Background technique [0002] Natural products derived from Streptomyces often have good biological activity and drug potential, and are an important source of antibiotics. However, with the abuse of antibiotics, the emergence of many "super bacteria" has brought huge challenges to the treatment of clinical pathogenic infections and other diseases, and some super bacteria have appeared incurable. In view of the current increasingly severe antibacterial situation, increasing the research and development of antibiotics, exploring and developing new antibiotics has become a top priority and an effective way to solve the...

Claims

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Application Information

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IPC IPC(8): C07D493/08C12P17/06A61P31/04A61P31/10C12R1/465
CPCC07D493/08C12P17/06Y02A50/30
Inventor 钱声艳刘建国杨彩玲李爱苹张权王倩
Owner ZUNYI MEDICAL UNIVERSITY
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