Tobramycin solution for inhalation and preparation method of tobramycin solution
A technology of tobramycin and solution, applied in the field of medicine, can solve the problems of high probability of bronchospasm and poor stability, and achieve the effects of realizing antioxidant effect, improving stability and improving curative effect.
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Embodiment 1
[0029] Dissolve 0.9g of sodium chloride in 140ml of water for injection at 30°C, stir until completely dissolved and inflate with nitrogen for 20 minutes, then add 15g of tobramycin, stir until completely dissolved, then add 5mol / L sulfuric acid to adjust the pH to 5.8, if necessary, use 1mol / L sodium hydroxide solution to adjust the pH value to 5.8, add water for injection to 200ml, stir for 15min, then filter with a 0.22μm filter, and fill it in a low-density polyethylene bottle to obtain Tobramycin solution for inhalation; the molar osmotic pressure of the tobramycin solution for inhalation obtained in this example is 247 mOsm / l.
Embodiment 2
[0031] Dissolve 0.9g of sodium chloride in 120ml of water for injection at a temperature of 28°C, stir until completely dissolved and inflate with nitrogen for 30 minutes, then inflate with carbon dioxide until the pH of the solution is 5.7, then add 1mg of cysteine and 12g of tobu Mycin, stir until completely dissolved, then add 3mol / L sulfuric acid to adjust the pH value to 5.9, if necessary, use 1mol / L sodium hydroxide solution to adjust the pH value to 5.9, add water for injection to 200ml, stir for 20min, and then use 0.22μm The tobramycin solution for inhalation was obtained by filtering it with a filter and filling it in a low-density polyethylene bottle; the osmotic pressure of the tobramycin solution for inhalation obtained in this example was 232 mOsm / l.
Embodiment 3
[0033] Dissolve 0.9g of sodium chloride in 140ml of water for injection at a temperature of 30°C, stir until completely dissolved and inflate with nitrogen for 20 minutes, then inflate with carbon dioxide gas until the pH of the solution is 5.7, then add 15g of tobramycin, stir until completely dissolved , then add 4mol / L sulfuric acid to adjust the pH value to 6.1, if necessary, use 1mol / L sodium hydroxide solution to adjust the pH value to 6.1, add water for injection to 200ml, stir for 30min, then filter with a 0.22μm filter, and fill The tobramycin solution for inhalation was obtained in a low-density polyethylene bottle; the molar osmotic pressure of the tobramycin solution for inhalation obtained in this example was 243 mOsm / l.
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