Application of anti-eno1 autoantibodies in screening pregnant women with AIT and predicting the risk of miscarriage

A technology for autoantibodies and pregnant women, applied in the field of biomedicine, can solve the problems of unclear clinical significance, no one has explored the relationship between ENO1Ab, and limited clinical application of antibodies, etc., and achieves the effect of broad application prospects

Active Publication Date: 2020-03-31
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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Problems solved by technology

Although it was reported in the early days that various autoantibodies such as ENO1Ab could be detected in women with systemic lupus erythematosus and antiphospholipid syndrome who had failed pregnancy, the clinical significance of their expression was not clear at that time
[0005] The technical problem in the existing technology is that no one has explored the correlation between the production of ENO1Ab and the increased risk of miscarriage in pregnant women with AIT, which also limits the clinical application of this antibody

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  • Application of anti-eno1 autoantibodies in screening pregnant women with AIT and predicting the risk of miscarriage
  • Application of anti-eno1 autoantibodies in screening pregnant women with AIT and predicting the risk of miscarriage
  • Application of anti-eno1 autoantibodies in screening pregnant women with AIT and predicting the risk of miscarriage

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Embodiment Construction

[0018] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments, but should not be construed as a limitation of the present invention. The experimental methods in the following examples, unless otherwise specified, are conventional methods, and the materials, reagents, etc. used in the following examples, unless otherwise specified, can be obtained from commercial sources.

[0019] The application of an anti-ENO1 autoantibody provided by the invention as a biomarker or a preparation kit for screening pregnant women with AIT and predicting the risk of miscarriage.

[0020] To clarify whether the production of ENO1Ab is the pathogenic factor leading to abortion in AIT mothers. This is the key to discuss the increased risk of miscarriage in pregnant women with AIT, but there are no effective prediction and prevention measures at present. Therefore, we conducted the following research:

[0021] 1. ENO1 has bee...

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Abstract

The invention belongs to the technical field of biomedicine, and concretely discloses application of predicting abortion risk of a pregnant woman suffering from AIT (autoimmune thyroiditis) through detecting the ENO1 (alpha-enolase) specific autoantibody (ENO1Ab) level in serum. The invention discovers that the existence of the ENO1Ab is closely related to the occurrence of abortion and the attackof placenta dysfunction, so that novel clinical application for timely screening out the AIT pregnant woman with high abortion risk is provided.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of an anti-ENO1 autoantibody in screening pregnant women with AIT and predicting the risk of miscarriage. Background technique [0002] Autoimmune thyroiditis (AIT) is one of the most common endocrine diseases, and the most representative autoantibodies are thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb). The positive rate of the above-mentioned thyroid autoantibodies in the general population during childbearing period is 10-20%, while the positive rate of TPOAb or TgAb in pregnant women is 2-17%, which varies with different ethnic groups. According to the latest investigation of our research group, the positive rates of TPOAb and TgAb in early pregnancy women in iodine-sufficient areas were 8.7% and 12.0%, respectively. This suggests that AIT is very common in pregnant women. [0003] A large number of studies have shown th...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/689G01N33/6893G01N2800/046G01N2800/368G01N2800/50
Inventor 李静卢一寒单忠艳滕卫平李晨嫣李健秦娟李慧孙溶励项阳王薇薇
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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