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Method for combined induction of increase in endogenous Lgr5+ liver stem cells and application of method

A liver stem cell and stem cell technology, applied in the direction of cell dissociation, artificially induced pluripotent cells, liver cells, etc., to achieve the effect of promoting tissue damage repair/regeneration, expanding the scope of application, and expanding the application method

Active Publication Date: 2018-05-01
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0010] The use of stem cells to treat chronic liver fibrosis has not been reported so far

Method used

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  • Method for combined induction of increase in endogenous Lgr5+ liver stem cells and application of method
  • Method for combined induction of increase in endogenous Lgr5+ liver stem cells and application of method
  • Method for combined induction of increase in endogenous Lgr5+ liver stem cells and application of method

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Embodiment Construction

[0079] The present invention is described in detail below in conjunction with embodiment. In order to make the object, technical solution and advantages of the present invention clearer and clearer, the present invention will be described in further detail below with reference to the accompanying drawings and examples, but the present invention is not limited to these examples.

[0080] Unless otherwise specified, the raw materials and catalysts in the examples of the present invention were purchased through commercial channels. Among them, Lgr5 (leucine-rich repeat-containing g-protein coupled receptor5) belongs to the G protein-coupled receptor family, which contains 17 leucine-rich repeat sequences and 7 a-helix transmembrane regions, and its N- and C- The terminal tail is flanked by cysteine-rich sequences, which can be expressed in various tissues such as gastrointestinal tract and hair follicles.

[0081] The in-depth study of embryonic stem cells (ESC) and the rise of ...

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Abstract

The invention discloses a method for combined induction of increase in endogenous Lgr5+ liver stem cells and an application of the method, and in particular a method for inducing the endogenous Lgr5+liver stem cells through combination of soluble protein molecules HGF and Rspo1. The soluble ligand can reach tissue stem cells through intravenous injection, and the soluble ligand, combined with a receptor, can activate the tissue stem cells. According to the method, the Lgr5+ liver stem cells are taken as targets. According to the method provided by the invention, on the basis of self-renewal and multifunctional differentiation capacities of various tissue and organ endogenous stem cells, the tissue and organ endogenous stem cells in a body are directly stimulated via the soluble molecules,so that self-renewal / regeneration of tissues and organs can be promoted; and from the aspects of application convenience, cost saving and safety, feasibility is enhanced.

Description

technical field [0001] The invention relates to the field of modern molecular biology technology, in particular to a method and application for jointly inducing the increase of endogenous Lgr5+ liver stem cells. Background technique [0002] The liver is a very important vital organ of the digestive system. It is responsible for regulating many important physiological activities, including glycogen storage, lipid metabolism, plasma protein secretion, foreign substance detoxification, bile secretion, etc. [0003] Loss of liver function is so diverse and important that within days organ failure, secondary hypotension, diabetes, brain damage and even death can result. Liver diseases, such as hepatic metabolic diseases, fulminant hepatic failure, hepatitis, cirrhosis, liver cancer, etc., are an important cause of death worldwide. [0004] At present, the treatment status of liver diseases is not optimistic. Liver dialysis technology can cope with the threat of liver function l...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P1/16C12N5/074C12N5/071A61K38/17
CPCA61K38/1703A61K38/1833C12N5/0671C12N5/0672C12N2509/00A61K2300/00
Inventor 周伟杰林媛
Owner SOUTHERN MEDICAL UNIVERSITY
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