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Glucan-gadolinium MRI nanometer developer and preparation method thereof

A technology of dextran and developing agent, which is applied in the field of preparation of nuclear magnetic resonance imaging agents, can solve the problems of tedious synthesis and instability of dendritic polymer carriers, and achieve good biocompatibility, high loading rate and simple preparation method Effect

Active Publication Date: 2018-04-13
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these systems still have certain limitations, for example, the synthesis of dendrimer carriers is cumbersome, liposome carriers are thermodynamically metastable, and may have the disadvantage of being unstable in the biological environment in vivo

Method used

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  • Glucan-gadolinium MRI nanometer developer and preparation method thereof
  • Glucan-gadolinium MRI nanometer developer and preparation method thereof
  • Glucan-gadolinium MRI nanometer developer and preparation method thereof

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Embodiment 1

[0039] Step 1: Dissolve 1.5g of dextran (molecular weight: 40000Da) in 30ml of water and stir until fully dissolved to form an aqueous solution of dextran.

[0040] The second step: dissolving 0.67g of ceric ammonium nitrate in water to prepare an aqueous solution of ceric ammonium nitrate.

[0041] Step 3: Dissolving 0.144 g of diallyl disulfide cross-linking agent in 0.5 ml of dimethyl sulfoxide to prepare cross-linking agent dimethyl sulfoxide solution B.

[0042] Step 4: Dissolve 1.224ml glycidyl acrylate monomer in 2.5ml dimethyl sulfoxide to prepare monomer dimethyl sulfoxide solution C.

[0043] Step 5: Nitrogen deoxidation for 1 hour, add dilute nitric acid solution containing 0.67g of ammonium cerium nitrate to the dextran aqueous solution under nitrogen protection and uniform stirring, adjust the pH between 1-2, react for 5 minutes, add monomer dimethyl Base sulfoxide solution C, react for 30min, add cross-linking agent dimethyl sulfoxide solution B after half an ho...

Embodiment 2

[0048] Step 1: Dissolve 1.5g of dextran (molecular weight: 40000Da) in 30ml of water and stir until fully dissolved to form an aqueous solution of dextran.

[0049] The second step: dissolving 0.67g of ceric ammonium nitrate in water to prepare an aqueous solution of ceric ammonium nitrate.

[0050] Step 3: Dissolve 0.144 g of diallyl disulfide cross-linking agent in 0.5 ml of dimethyl sulfoxide to prepare cross-linking agent dimethyl sulfoxide solution B.

[0051] Step 4: Dissolve 0.75 ml of methyl acrylate monomer in 2.5 ml of dimethyl sulfoxide to prepare monomer dimethyl sulfoxide solution C.

[0052] Step 5: Nitrogen deoxidation for 1 hour, add dilute nitric acid solution containing 0.67g of ammonium cerium nitrate to the dextran aqueous solution under nitrogen protection and uniform stirring, adjust the pH between 1-2, react for 5 minutes, add monomer dimethyl Base sulfoxide solution C, reacted for 30min, added cross-linking agent dimethyl sulfoxide solution B, reacted ...

Embodiment 3

[0057] Step 1: Dissolve 1.5g of dextran (molecular weight: 40000Da) in 30ml of water and stir until fully dissolved to form an aqueous solution of dextran.

[0058] The second step: dissolving 0.67g of ceric ammonium nitrate in water to prepare an aqueous solution of ceric ammonium nitrate.

[0059] Step 3: Dissolve 0.122 g of N,N-methylenebisacrylamide cross-linking agent in 5 ml of water to prepare cross-linking agent aqueous solution B.

[0060] Step 4: Dissolve 0.75 ml of methyl acrylate monomer in 2.5 ml of dimethyl sulfoxide to prepare monomer dimethyl sulfoxide solution C.

[0061] Step 5: Nitrogen deoxidation for 1 hour, add dilute nitric acid solution containing 0.67g of ammonium cerium nitrate to the dextran aqueous solution under nitrogen protection and uniform stirring, adjust the pH between 1-2, react for 5 minutes, add monomer dimethyl sulfoxide solution C, reacted for 30 minutes, added cross-linking agent aqueous solution B, and reacted for 8 hours at 30°C. Im...

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Abstract

The invention discloses a glucan-gadolinium MRI nanometer developer and a preparation method of the glucan-gadolinium MRI nanometer developer. According to a carrier disclosed by the invention, the glucan-polyacrylate nano-carrier is efficiently synthesized through one step by adopting a grafting copolymerization reaction induction self-assembly method, hydrazino is grafted through modification, gadolinium ions are grafted through physical or chemical bonding, finally, the glucan-gadolinium MRI nanometer developer is prepared, and the developer is a nuclear magnetic resonance developer and isapplied to the field of biomedicine. The preparation method disclosed by the invention is simple and efficient, the yield is high, the cost is low, for the prepared nanometer developer, the particle size is uniform, the stability is good, the loading rate of the gadolinium ions is high, the property is excellent, the longitudinal relaxation rate is high, the longitudinal relaxation rate of the prepared nanometer developer provided by the invention is 7-14 times of that of a commercial dimeglnmine gadopentetate injection (Magnevist ), and in addition, the system is low in toxicity, has good biocompatibility, and has a wide application prospect in the fields of disease diagnosis and treatment.

Description

technical field [0001] The invention relates to the field of preparation of nuclear magnetic resonance imaging agents used in the biomedical field, in particular to a dextran-gadolinium MRI nano imaging agent with high relaxation rate and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (MRI) has many excellent properties, such as non-invasiveness, non-ionizing radiation, high spatial resolution, and high soft tissue resolution. It is widely used in clinical practice and plays a vital role in the diagnosis of various diseases. MRI contrast agents can be divided into two categories, enhancing T 1 T of contrast signal 1 Weighted contrast agents (positive enhancement contrast, brightness contrast agents) and reduced T 2 T of contrast signal 2 Weighted contrast agents (negative enhancement contrast, dark contrast agents). The effectiveness of an MRI contrast agent is determined by its longitudinal relaxation potency r 1 and transverse r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/18B82Y5/00B82Y15/00C08F251/00C08F220/32
CPCA61K49/126A61K49/1863B82Y5/00B82Y15/00C08F251/00C08F220/325
Inventor 窦红静王灏徐源
Owner SHANGHAI JIAO TONG UNIV
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