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Application of Yangxinshi Tablets in Preparation of Drugs for Treating Depression

A technology for Yangxin's tablet and depression, applied in the field of medicine, can solve problems such as no reports on the application of Yangxin's tablet as an antidepressant drug, and achieve the effects of good development prospect, less side effects and definite curative effect.

Active Publication Date: 2020-06-30
SHANGAI PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And so far, many literatures are reporting the clinical observation effect of Yangxinshi Tablets on chronic heart failure such as angina pectoris and coronary heart disease, but there is no report on the application of Yangxinshi Tablets as an antidepressant drug

Method used

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  • Application of Yangxinshi Tablets in Preparation of Drugs for Treating Depression
  • Application of Yangxinshi Tablets in Preparation of Drugs for Treating Depression
  • Application of Yangxinshi Tablets in Preparation of Drugs for Treating Depression

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0010] Example 1: Effect test of Yangxinshi Tablets on rats with chronic mild unpredictable stimulus depression

[0011] 1 Experimental method

[0012] 1.1 Experimental animals and grouping

[0013] Experimental animals were provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd.: 80 SD male rats, SPF grade, weighing 180-220 g, animal production license number: SCYK ​​(Shanghai) 2013-0016. Before the experiment, the rats were placed in a normal experimental environment for adaptive feeding, food and water were provided normally, and a 12-hour light cycle was ensured. The 80 rats were randomly divided into blank control group, model group, fluoxetine group, high-dose Yangxinshi Tablets group, medium-dose Yangxinshi Tablets group, and low-dose Yangxinshi Tablets group.

[0014] 1.2 Animal modeling and administration

[0015] During the model preparation process, rats in the model group, fluoxetine group, high-dose Yangxinshi Tablet group, medium-dose Yangxinshi Tablet...

example 2

[0050] Example 2: Effect test of Yangxinshi tablets on mice with vascular depression induced by cerebral ischemia-reperfusion

[0051] 1 Experimental method

[0052] 1.1 Experimental animals and grouping

[0053] Experimental animals were provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd.: 90 ICR male mice, SPF grade, weighing 18-22g, animal production license number: SCYK ​​(Shanghai) 2013-0016. Before the experiment, the mice were placed in a normal experimental environment for adaptive feeding, food and water were provided normally, and a 12-hour light cycle was ensured. The 90 mice were randomly divided into sham operation group, model group, fluoxetine group, High-dose Yangxinshi Tablets group, medium-dose Yangxinshi Tablets group, and low-dose Yangxinshi Tablets group.

[0054] 1.2 Animal modeling and administration

[0055] After the mice in the model group, fluoxetine group, high-dose Yangxinshi tablet group, middle-dose Yangxinshi tablet group, and low...

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PUM

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Abstract

The invention provides application of Yangxin Shi Pian to preparation of depression treating drugs. Pharmacodynamic tests prove that Yangxin Shi Pian has a remarkable effect in treating depression. Therefore, Yangxin Shi Pian can be used for preparing depression treating drugs, and has a good development prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the preparation of Yangxinshi Tablets composed of astragalus, codonopsis, salvia, kudzu root, epimedium, hawthorn, rehmannia glutinosa, angelica, berberine, vinegar corydalis, ganoderma lucidum, ginseng and roasted licorice. For use in drugs for the treatment of depression. Background technique [0002] Depression is a common mental disorder that can cause mental and physical damage. The main features of depression are low mood, loss of happiness, even pessimistic world-weariness, and may have suicide attempts or behaviors. This state is accompanied by fatigue, inattention, sleep disturbance, and cognitive and language dysfunction. Depression seriously plagues patients' daily life, study and work, and is one of the sources of heavy burdens on families and society. According to the World Health Organization, about 350 million people suffer from depression, which has become one of the imp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P25/24
CPCA61K36/074A61K36/232A61K36/258A61K36/296A61K36/344A61K36/48A61K36/481A61K36/484A61K36/537A61K36/66A61K36/718A61K36/734A61K36/804A61K2300/00
Inventor 叶冠赵亚红毕晓莹张海薛丹高越柴逸峰刘彦君洪毅高莉
Owner SHANGAI PHARMA GRP CO LTD
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