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Application of Babaodan in the preparation of medicine for treating obesity

An obesity, Babaodan technology, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve problems such as the safety impact of western medicine, and achieve the effect of significant weight loss effect, definite curative effect, and good prospect of development and use.

Active Publication Date: 2021-11-02
XIAMEN TRADITIONAL CHINESE MEDICINE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The safety problem of western medicine affects its wide application to a certain extent
However, due to the accelerated pace of modern life and the increase in work pressure, the implementation of the best anti-obesity method of changing lifestyle and controlling fat intake also has certain restrictions.

Method used

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  • Application of Babaodan in the preparation of medicine for treating obesity
  • Application of Babaodan in the preparation of medicine for treating obesity
  • Application of Babaodan in the preparation of medicine for treating obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Growth Index

[0016] Weigh and record the mice every week, observe the body weight of the mice in each group, and compare the changes in body weight before and after the drug administration. ), body weight growth rate (%)=(final weight-initial weight) / initial weight×100%.

[0017] Determination of LEE'S index value: Accurately measure body length (length from nose to anus) and tail length under anesthesia, and then calculate LEE'S INDEX value according to the following formula:

[0018] LEE'S INDEX=weight (g)^(1 / 3)*1000 / body length (cm)

[0019] See the experimental results figure 1 and Table 1.

[0020] Table 1

[0021]

[0022] * represents P<0.05 compared with ND group; # represents P<0.05 compared with HFD group (X±S, n=6).

[0023] Compared with the ND group, the body weight of the HFD group continued to increase; compared with the HFD group, the body weight of the mice in the ND group, the HFD+BBD group and the ND+BBD group decreased significant...

Embodiment 2

[0024] Example 2 Fat content

[0025] After the growth index experiment in Example 1 was completed, the mice were dissected to observe the fat accumulation around the liver, and the fat weight was weighed.

[0026] See the experimental results figure 2 and image 3 , the body fat content of the mice in the HFD group increased significantly, and the body fat content of the mice in the other three groups decreased to varying degrees. Babaodan significantly reduces fat content in obese mice.

Embodiment 3

[0027] Example 3 Pathological examination

[0028] After the growth index experiment in Example 1 was completed, the mouse liver was taken, and the left liver lobe was sliced, stained with oil red, fixed, and the changes of liver fat deposition in mice in each group were evaluated.

[0029] See the experimental results Figure 4 , the fat deposition in the liver of the mice in the HFD group, and the fat deposition in the liver of the mice in the other three groups were improved to varying degrees. Babaodan can significantly reduce liver fat deposition in obese mice.

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Abstract

The invention provides the application of Babao Dan in the preparation of medicine for treating obesity. Pharmacological experiments have found that the weight loss effect of the medicine prepared by Babao Dan is remarkable. Therefore, Babaodan can be used to prepare medicines for treating obesity, and has a good prospect for development and application.

Description

technical field [0001] The invention belongs to the field of new indications of medicines, and in particular relates to the use of Babaodan in the preparation of medicines for preventing obesity. Background technique [0002] Obesity has become one of the most important public health problems in the world. It is clinically considered that a body mass index ≥ 24 is an overweight patient. The root cause of obesity is the imbalance between energy intake and output, leading to excessive accumulation of body fat, and various factors such as genes, endocrine, physiology, nutrition and social environment will cause energy imbalance. In the past 5 years, the incidence of overweight and obesity in some countries has nearly doubled, and the overweight and obesity rate in the world has exceeded 42%, and the proportion of women is much higher than that of men. [0003] Obesity is also one of the main risk factors for the occurrence of chronic diseases such as hypertension, dyslipidemia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P3/04A61K35/618A61K35/583A61K35/55A61K35/413A61K35/32
Inventor 刘彦君韩志鹏柯樱卫立辛沈锋赵亚红安泳潼侯晓娟包侠萍郑珊珊叶菲高璐张黎
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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