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Application of Babaodan in the preparation of medicine for treating non-alcoholic fatty liver

A non-alcoholic and fatty liver technology is applied in the field of Babao Dan in the preparation of medicines for the treatment of non-alcoholic fatty liver, and achieves the effects of exact curative effect, good development and application prospects, and remarkable effect.

Active Publication Date: 2021-11-02
XIAMEN TRADITIONAL CHINESE MEDICINE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Babaodan is clinically used for various damp-heat syndromes, including jaundice caused by damp-heat, gastrointestinal symptoms, and the treatment of liver and liver protection. There is no report of Babaodan in the preparation of drugs for the treatment of non-alcoholic fatty liver disease

Method used

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  • Application of Babaodan in the preparation of medicine for treating non-alcoholic fatty liver
  • Application of Babaodan in the preparation of medicine for treating non-alcoholic fatty liver
  • Application of Babaodan in the preparation of medicine for treating non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 growth index

[0019] Weigh and record the mice every week, observe the body weight of the mice in each group, and compare the changes in body weight before and after the drug administration. ), body weight growth rate (%)=(final weight-initial weight) / initial weight×100%.

[0020] Determination of LEE'S index value: Accurately measure body length (length from nose to anus) and tail length under anesthesia, and then calculate LEE'S INDEX value according to the following formula:

[0021] LEE'S INDEX=weight (g)^(1 / 3)*1000 / body length (cm)

[0022] After the above experiment was over, the liver was quickly taken out and weighed, and the liver index was calculated (liver weight / body weight*100%)

[0023] See the experimental results figure 1 As in Table 1, compared with the ND group, the body weight of the HFD group continued to increase; compared with the HFD group, the body weight of the mice in the ND group, the HFD+BBD group and the ND+BBD group decreas...

Embodiment 2

[0027] Embodiment 2 fat content

[0028] After the growth indicator experiment in Example 1 was completed, the mice were dissected to observe the fat accumulation around the liver, and the weight of the fat was weighed.

[0029] See the experimental results figure 2 and image 3 , the body fat content of the mice in the HFD group increased significantly, and the body fat content of the mice in the other three groups decreased to varying degrees. Babaodan can significantly reduce the fat content of mice.

Embodiment 3

[0030] Embodiment 3 Pathological examination

[0031] After the experiment on the growth index in Example 1 was completed, the mouse liver was taken, and the left liver lobe was sliced, stained with oil red, fixed, and the changes of liver fat deposition in mice in each group were evaluated.

[0032] See the experimental results Figure 4 , the fat deposition in the liver of the mice in the HFD group, and the fat deposition in the liver of the mice in the other three groups were improved to varying degrees. Babaodan can significantly reduce liver fat deposition in mice.

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PUM

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Abstract

The invention provides the application of Babao Dan in the preparation of medicine for treating non-alcoholic fatty liver. Pharmacological experiments have found that Babaodan has a significant effect in treating non-alcoholic fatty liver. Therefore, Babaodan can be used to prepare medicines for treating non-alcoholic fatty liver, and has a good prospect for development and use.

Description

technical field [0001] The invention belongs to the field of new indications of medicines, and specifically relates to the use of Babaodan in the preparation of medicines for treating non-alcoholic fatty liver. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver injury closely associated with insulin resistance (IR) and genetic susceptibility, characterized by hepatic steatosis and fat accumulation without a history of excessive alcohol consumption clinical syndrome. Its impact on life and health is getting bigger and bigger, and people are paying more and more attention to it. [0003] At present, the prevalence of nonalcoholic fatty liver disease in the global general population is as high as 20% to 30%. The incidence of hepatitis and alcoholic liver disease has become the most common liver disease. The disease used to be common in western countries, but with the improvement of living standards in my country and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P1/16A61K35/413A61K35/32A61K35/55A61K35/583A61K35/618
Inventor 韩志鹏刘彦君卫立辛沈锋赵亚红安泳潼盛丹丹关斌南淑华井莹莹宗晨李小勇
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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