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Applications of eight-treasure pill in preparing medicines for preventing obesity

An obesity, Babaodan technology, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve problems such as the safety impact of western medicine, and achieve the effect of obvious obesity prevention, obvious effect, and good prospect of development and use.

Active Publication Date: 2018-01-09
XIAMEN TRADITIONAL CHINESE MEDICINE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The safety problem of western medicine affects its wide application to a certain extent

Method used

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  • Applications of eight-treasure pill in preparing medicines for preventing obesity
  • Applications of eight-treasure pill in preparing medicines for preventing obesity
  • Applications of eight-treasure pill in preparing medicines for preventing obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 growth index

[0015] Weigh and record the mice every week, observe the body weight of the mice in each group, and compare the changes in body weight before and after the drug administration. ), body weight growth rate (%)=(final weight-initial weight) / initial weight×100%.

[0016] Determination of LEE'S index value: Accurately measure body length (length from nose to anus) and tail length under anesthesia, and then calculate LEE'S INDEX value according to the following formula:

[0017] LEE'S INDEX=weight (g)^(1 / 3)*1000 / body length (cm)

[0018] See the experimental results figure 1 As shown in Table 1, Babaodan can significantly inhibit the weight gain of C57 mice and reduce the LEE'S index.

[0019] Table 1

[0020]

[0021] * represents P<0.05 compared with the normal group; # represents P<0.05 compared with the model group (X±S, n=7).

Embodiment 2

[0022] Embodiment 2 fat content

[0023] After the growth index experiment in Example 1 was completed, the mice were dissected to observe the fat accumulation around the liver, and the fat weight was weighed.

[0024] See the experimental results figure 2 , Compared with the normal group, the body fat content of the mice in the HFD group was significantly increased, and the fat content in the HFD+BBD group was significantly reduced after intragastric administration.

Embodiment 3

[0025] Embodiment 3 serological examination

[0026] After the growth index experiment in Example 1 was completed, the mice were fasted for 6 hours, blood was collected from the mice, centrifuged at 3000 r / min for 10 minutes, the serum was separated for testing, and the serum TC and TG levels were measured.

[0027] See the experimental results image 3 , the content of serum triglyceride (TG) and total cholesterol (TC) in the HFD group mice was significantly increased, and the TG content was significantly decreased in the HFD+BBD group, and the TC content was slightly decreased.

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Abstract

The invention provides applications of an eight-treasure pill in preparing medicines for preventing obesity. The pharmacological experiment shows that the medicines prepared by adopting the eight-treasure pill have an obvious effect in preventing obesity, therefore, the eight-treasure pill can be used for preparing the medicines for preventing obesity, and has good development and application prospects.

Description

technical field [0001] The invention belongs to the field of new indications of medicines, and in particular relates to the use of Babaodan in the preparation of medicines for preventing obesity. Background technique [0002] Obesity intervention work is the focus of the whole society. Obesity is one of the main risk factors inducing the occurrence of chronic diseases such as hypertension, dyslipidemia, type 2 diabetes, cardiovascular disease, insomnia and apnea. It is clinically considered that a body mass index ≥ 24 is an overweight patient. Obesity prevention is mainly carried out in high-risk groups of obesity, or individuals who are already overweight, or have biological indicators of obesity but are still not obese, with the purpose of preventing weight gain and reducing the prevalence of weight-related diseases. However, due to the accelerated pace of modern life and increased work pressure, the implementation of the best anti-obesity methods, such as changing lifes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P3/04A61K35/413A61K35/583A61K35/32A61K35/618A61K35/55
Inventor 卫立辛刘彦君沈锋韩志鹏赵亚红安泳潼盛丹丹墙世发杨惠婉赵秋东刘文婷李蓉
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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