Photoaging-inhibition compound titanium dioxide gel composition

A technology of gel composition and titanium dioxide, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of easy sensitization, inability to prevent photoaging, damage, etc.

Inactive Publication Date: 2018-03-23
陈有平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In order to avoid the damage of ultraviolet rays to the skin of outdoor workers, zinc oxide and titanium dioxide are used in the prior art to absorb ultraviolet rays, but the above-mentioned ingredients themselves cannot prevent photoaging caused by ultraviolet rays, and are prone to sensitization

Method used

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  • Photoaging-inhibition compound titanium dioxide gel composition
  • Photoaging-inhibition compound titanium dioxide gel composition
  • Photoaging-inhibition compound titanium dioxide gel composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0013] Sarcsteroid F is prepared according to the method disclosed in the Chinese patent document CN102250181 to prepare the Sarcsteroid F raw material with a content of more than 98%. The structural formula of Sarcsteroid F is:

[0014]

[0015] The gel composition that is used for anti-ultraviolet that each embodiment makes is 1000g, and preparation method is

[0016] Mix carbomer with 400ml of distilled water and fully swell to obtain liquid (1), use a pH regulator to adjust the pH of liquid (1) to 6-7, dissolve the antibacterial preservative and Sarcsteroid F in the solvent (volume ratio 1:0.3 After adding ethanol and DMSO) gradually into solution (1) and stirring evenly; adding titanium dioxide, surfactant and humectant to the remaining amount of water, then gradually adding solution (1) and stirring evenly to obtain a gel composition.

Embodiment 1～6

[0017] Embodiment 1~6 prescription is as follows (unit: g)

[0018]

Embodiment 1

[0019] Pharmacological Example 1 Ultraviolet Absorption Contrast Experiment

[0020] 1. Selection of comparative drugs, using cosmetic grade nano-TiO2 (produced by Shanghai Jianghu Group) as comparative drugs.

[0021] 2. Determination of light transmittance: use the meter to measure the UVA region 400, 380, 360, 340 and 320nm, UVB region 320, 300 and 280nm, UVC region 280, 260, 246, 240, 220 and 200nm, measure the The light transmittance of the test solution is measured in parallel three times, and the average absorbance is calculated: A%=100%-T%.

[0022] According to the method of the national standard QB / T2410-1998, the absorbance values ​​of sunscreen samples at 280nm, 290nm, 300nm, 310nm in the UVB area and 320nm, 340nm, 360nm, 380nm, 400nm in the UVA area were measured, and the UVB area was obtained respectively and average absorbance values ​​at wavelengths in the UVA region. Adopt quartz cell cuvette (1.2cm*4.5cm) and American 3M company to produce medical tape (3M ...

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Abstract

A photoaging-inhibition compound titanium dioxide gel composition is characterized in that the gel contains Sarcsteroid F used as an active component, titanium dioxide and at least one auxiliary material suitable for gel; and the gel composition contains 0.3-0.4 wt% of the Sarcsteroid F and 1-2 wt% of the titanium dioxide, and the auxiliary material is prepared from one or more selected from 0.5-1.5% of carbomer, 4-6% of a humectant, a solvent with the amount being a minimum amount for realizing the dissolving of the Sarcsteroid F, a preservative, 0.5-1% of a surfactant and a pH adjuster, andthe balance of water.

Description

Technical field: [0001] The invention provides an anti-ultraviolet composition for external use. Background technique: [0002] In order to avoid the damage of ultraviolet rays to the skin of outdoor workers, zinc oxide and titanium dioxide are used in the prior art to absorb ultraviolet rays, but the above-mentioned ingredients themselves cannot prevent photoaging caused by ultraviolet radiation, and are prone to sensitization. Therefore how to provide a kind of external composition improved on the basis of the existing external composition containing titanium dioxide and can inhibit the photoaging caused by ultraviolet radiation has become a problem to be solved urgently in the prior art Invention content: [0003] During the research, we were surprised to find that when a steroid compound called Sarcsteroid F disclosed in Chinese patent document CN102250181A is used externally together with titanium dioxide, it can not only significantly improve the effect of absorbing ...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K9/06A61P17/16A61P17/18A61K31/575
CPCA61K9/0014A61K9/06A61K31/575A61K33/24A61K47/32A61K2300/00
Inventor 宋宇豪陈有平
Owner 陈有平
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