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Combined medication method of prednisone and aspirin and application of method to preparation of combined medicine for treating anti-nuclear antibody positive infertility

A technology of aspirin and drug combination, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, and can solve the problems of embryo cleavage rate, pregnancy rate decrease, and lack of unity

Inactive Publication Date: 2018-03-16
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further studies have found that ANA exists in follicular fluid and embryos of women with positive antinuclear antibodies, and is positively correlated with serum ANA concentration. ANA can have a significant adverse effect on the outcome of IVF-ET
[0005] Although it has been reported in the literature that antinuclear antibodies affect egg maturation, which can easily lead to a decrease in embryo cleavage rate, implantation rate, and pregnancy rate, there is still no unified view on whether adjuvant therapy is necessary for ANA-positive infertile women to undergo IVF / ICSI-ET. In the prior art, the selection of relevant drugs and the time of starting treatment, drug dosage and treatment time are not clear

Method used

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  • Combined medication method of prednisone and aspirin and application of method to preparation of combined medicine for treating anti-nuclear antibody positive infertility
  • Combined medication method of prednisone and aspirin and application of method to preparation of combined medicine for treating anti-nuclear antibody positive infertility
  • Combined medication method of prednisone and aspirin and application of method to preparation of combined medicine for treating anti-nuclear antibody positive infertility

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, ANA detection:

[0023] ANA in patient serum was detected using an antinuclear antibody kit (Trinity Biotech, Ireland). The antinuclear antibodies detected by this kit include Anti-dsDNA, Anti-scl-70, anti-PM-scl, Anti-Rib-p , anti-Jo-1 and anti-centromere, histone antibodies, anti-SSa, anti-SSb, anti-RNP. The absorbance (OD value) measured by the spectrophotometer represents the concentration of ANA in the blood, ANA concentration=sample OD value / corrected OD value, if the value is greater than 1, it is ANA positive, and if it is less than 1, it is ANA negative. The sensitivity and specificity of this detection method were 100% and 92.8%, respectively. All operations are strictly in accordance with the procedures in the manual. All patients were tested again for ANA in serum before ovulation induction.

Embodiment 2

[0024] Example 2, IVF-ET program and collection of clinical data

[0025] All patients were treated with a long-term plan of pituitary downregulation, that is, a long-acting gonadotropin-releasing hormone agonist was used in the mid-luteal phase, and gonadotropin was used to induce ovulation after the pituitary gland was completely downregulated. The starting dose of gonadotropin was based on the age of the patient. , the number of antral follicles and the basal FSH level, and the dosage of gonadotropins should be appropriately adjusted according to the patient's ovarian response during the process of superovulation stimulation. When vaginal ultrasound shows at least 2 follicles with a diameter of 18mm or at least 3 follicles with a diameter of 17mm On the day of intramuscular injection of HCG 5000-10000IU, eggs were retrieved 36 hours after HCG injection, and eggs were fertilized by in vitro fertilization or cytoplasmic sperm injection according to the man’s semen on the day o...

Embodiment 3

[0026] Embodiment 3, the determination of treatment plan and statistical analysis method

[0027] 1. The drug treatment plan is as follows:

[0028]This clinical study is divided into two parts, one part is the control study between the treatment group and the untreated group, the included patients are divided into the drug treatment group and the drug non-treatment group, and the relevant clinical data of the two groups are collected for comparative analysis; Before and after comparison, including the comparative analysis of the period data of the treatment group and the untreated data of the previous period, and the comparative analysis of the period data of the untreated group and the untreated data of the previous period. The treatment plan is to choose prednisone 10mg combined with aspirin 100mg per day. The treatment starts three months before ovulation induction. Drug therapy was also discontinued for ET failure.

[0029] 2. Sample size calculation and statistical ana...

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Abstract

The invention discloses a combined medication method of prednisone and aspirin and application of the method to preparation of a combined medicine for treating anti-nuclear antibody positive infertility. According to the scheme of the invention, prednisone and aspirin are used to perform combined medication to treat the anti-nuclear antibody positive infertility in three months before ovulation induction. Through comparison treatment, the fertility rate, the planting rate and the pregnancy rate in a treatment group are higher than those in a non-treatment group, and the abortion rate in the non-treatment group is higher. Through comparison on IVF-ET between the cycle and the last cycle in the treatment group, the outcome indicates that the fertility rate, the planting rate and the pregnancy rate in the treatment cycle are higher than those in the last non-treatment cycle, and the abortion rate in the cycle after treatment is lower. By adoption of the scheme of the invention, the prednisone serving as immunosuppression is used in three months before ovulation induction to serve as anticoagulation aspirin treatment, so that the reproductive outcome of the anti-nuclear antibody positive women can be improved.

Description

technical field [0001] The invention relates to the technical field of medicine and disease treatment, in particular to a method for combining prednisone and aspirin and its application in preparing combined medicine for treating antinuclear antibody-positive infertility. Background technique [0002] Since the birth of the first test-tube baby in 1978, nearly 5 million test-tube babies have been born worldwide. Assisted reproductive technology has brought hope to infertile couples. In recent years, with the increase of infertile couples and the opening of China's second-child policy, assisted reproductive technology will play an increasingly important role, but in assisted reproduction, in vitro fertilization-embryo transfer or cytoplasmic sperm injection-embryo transfer The clinical pregnancy rate of the treatment cycle is about 40%-50%, indicating that there are various reasons for the failure of assisted reproduction, such as: anatomical factors, endocrine status, embryo...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K31/573A61P15/08
CPCA61K31/573A61K31/616
Inventor 钟依平沈晓婷郭希陈明辉李宇彬
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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