Method for determining fingerprint of Qibai Pingfei granule, and fingerprint of granule

A fingerprint and particle technology, applied in instruments, measuring devices, scientific instruments, etc., to achieve high precision, accurate authenticity, and good reproducibility

Active Publication Date: 2018-03-09
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the fingerprint of the compound prescription

Method used

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  • Method for determining fingerprint of Qibai Pingfei granule, and fingerprint of granule
  • Method for determining fingerprint of Qibai Pingfei granule, and fingerprint of granule
  • Method for determining fingerprint of Qibai Pingfei granule, and fingerprint of granule

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Embodiment Construction

[0052] The embodiments of the present invention will be described in detail below in conjunction with the examples. If no specific conditions are indicated in the examples, it will be carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0053] 1 Fingerprint and content determination

[0054] 1.1 Instruments and reagents

[0055] Ultimate 3000HPLC, DAD ultraviolet detector (Thermo Fisher Scientific Corporation of the United States); MettlerAE240 electronic analytical balance (Swiss Mettler company); Mettler XP6 electronic analytical balance (Swiss Mettler company); Centrifuge 5415D high-speed centrifuge ( Eeppendorf, Germany); Milli-Q Academic water purifier (Millipore, USA); KQ-250DB ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.).

[0056] Schizandrin A reference substance (ba...

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Abstract

The invention discloses a method for determining the fingerprint of a Qibai Pingfei granule, and the fingerprint of the granule. The method comprises the following steps: respectively carrying out extraction on a Qibai Pingfei granule sample and schizandrin by using a methanol solution to obtain a sample solution and a reference substance solution, and carrying out high performance liquid chromatography on the sample solution and the reference substance solution by using the schizandrin, caffeic acid, ferulic acid, deoxyschizandrin, schisandrin B and schisantherin A as reference substances toobtain the fingerprint. The fingerprint of the Qibai Pingfei granule, established by using the method, can effectively characterize the quality of the Qibai Pingfei granule, and is in favor of comprehensively monitoring the quality of medicinal materials. The method has the advantages of simplicity, stability, high precision and good reappearance, and can be used to rapidly and accurately identifythe authenticity and the quality.

Description

technical field [0001] The invention belongs to the technical field of quality identification of traditional Chinese medicines, in particular to a method for determining the fingerprints of Qibaipingfei granules and the fingerprints of Qibaipingfei granules established by the method. Background technique [0002] Fingerprint of traditional Chinese medicine refers to the chromatogram or spectrum that can mark the chemical characteristics of some traditional Chinese medicinal materials or preparations after proper treatment and certain analysis methods. Traditional Chinese medicine fingerprint is a comprehensive and quantifiable means of identification. It is based on the systematic research on the chemical components of traditional Chinese medicine and is mainly used to evaluate the authenticity, goodness and stability of the quality of Chinese medicinal materials and semi-finished products of traditional Chinese medicine preparations. "Integrity" and "ambiguity" are its sali...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/06G01N30/88
Inventor 萧伟付娟张海弢李家春王伟胡军华黄文哲王振中
Owner JIANGSU KANION PHARMA CO LTD
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