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Compound betamethasone 17-valerate otic gel used for pet and preparation method of compound betamethasone 17-valerate otic gel

A technology of metasone valerate and gel, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, antifungal agents, etc., which can solve the problem of no effect of fungal infection, poor adhesion of drops, Short action time and other problems, to achieve the effect of improving comprehensive treatment effect, low equipment requirements, and inhibiting keratin abnormalities

Inactive Publication Date: 2018-03-09
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patents used to treat otitis externa in pets are all ear drops or ointments, such as the patent "Compound Liquid Drops for Pet Ear Canal Diseases" (application publication number CN105560252A, application publication date 2016.05.11), which is used for mite infection caused by For the treatment of otitis media in pets, the formula of this patent is complicated, including four drugs: levofloxacin, dexamethasone, lidocaine and permethrin, and the drops have poor adhesion and short action time
The patent "A Preparation Method of Enrofloxacin Ointment for Animals" (application publication number CN103784461A, application publication date 2014.05.14), uses enrofloxacin as the main drug, has good antibacterial effect, but has no effect on fungal infection Effect

Method used

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  • Compound betamethasone 17-valerate otic gel used for pet and preparation method of compound betamethasone 17-valerate otic gel
  • Compound betamethasone 17-valerate otic gel used for pet and preparation method of compound betamethasone 17-valerate otic gel
  • Compound betamethasone 17-valerate otic gel used for pet and preparation method of compound betamethasone 17-valerate otic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 0.5 g of betamethasone valerate, 20 g of florfenicol sodium succinate, 30 g of clotrimazole, 70 g of carboxypropyl cellulose, 4 g of ethylparaben, 2 g of dibutyl hydroxytoluene, 200 g of glycerin, Water ethanol 400g, distilled water 273.5g.

Embodiment 2

[0025] Weigh 2 g of betamethasone valerate, 30 g of florfenicol sodium succinate, 5 g of clotrimazole, 50 g of carboxypropyl cellulose, 5 g of ethylparaben, 1 g of dibutyl hydroxytoluene, 150 g of glycerin, anhydrous Ethanol 300g, distilled water 457g.

Embodiment 3

[0027] Take betamethasone valerate 3g, florfenicol sodium succinate 5g, clotrimazole 20g, carboxypropyl cellulose 60g, ethylparaben 0.5g, dibutylhydroxytoluene 0.5g, glycerin 100g, 350g of absolute ethanol, 461g of distilled water.

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PUM

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Abstract

The invention relates to a compound betamethasone 17-valerate otic gel used for a pet and a preparation method of the compound betamethasone 17-valerate otic gel, and belongs to the technical field ofpet medicines. Betamethasone 17-valerate, florfenicol sodium succinate and clotrimazole are combined in use and can treat acute and chronic otitis externa caused by bacteria and fungus. The gel has agood anti-inflammatory effect, is wide in antibacterial spectrum, and achieves the effect of in-depth treatment, and the irritation is low.

Description

technical field [0001] The invention belongs to the technical field of pet medicine, in particular to a compound betamethasone valerate ear gel for pets and a preparation method thereof. Background technique [0002] With the development of my country's social economy and the acceleration of urbanization, people's living patterns have changed and their living standards have improved significantly. The ensuing problems of independence, isolation, personalization and aging of urban and rural households have become increasingly prominent, and residents' leisure, consumption and emotional sustenance methods have also changed. Keeping pets has become a part of more and more people's lives. Pets, as human companion animals, are increasing in number, especially in large and medium-sized cities. [0003] Otitis is a common disease in pets, of which otitis externa is the most common. The etiology of otitis externa is mainly due to various factors such as bacterial, fungal, and para...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/06A61K47/10A61K47/38A61P31/04A61P31/10A61P27/16A61K31/165A61K31/4174
CPCA61K9/0046A61K9/06A61K31/165A61K31/4174A61K31/573A61K47/10A61K47/38A61K2300/00
Inventor 谢玲玲李旭东刘爱玲夏雪林刘拓
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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