Application of ABCG1 gene as molecular marker for diagnosis of exposure to heavy ion radiation

Abstract

The invention relates to application of an ABCG1 gene as a molecular marker to preparation of a reagent for diagnosis of exposure to heavy ion radiation, belonging to the field of application of genetic molecular markers. As the ABCG1 gene is used as the molecular marker for detection of exposure to heavy ion radiation, detection is more convenient and accurate and a radiation dose can be determined.

Description

technical field [0001] The present invention generally relates to the use of molecular markers in the preparation of reagents for the diagnosis of diseases or health conditions, and in particular to the use of molecular markers in the preparation of reagents / reagent sets for the diagnosis of radiation exposure. Background technique [0002] Ionizing radiation is radiation that can cause the ionization of matter. Heavy ions are a kind of dense ionizing radiation with high energy transfer linear density, which can cause serious damage to the human body. At the cellular level, heavy ion radiation damage mainly includes decreased cell survival, cell cycle arrest, and chromosomal aberrations. For the damage caused by heavy ion radiation to the human body, the existing detection methods mainly include MTT colorimetry, flow cytometry, and chromosome and micronucleus detection methods, but the disadvantage of these methods is that they can only detect the degree of radiation damage...

AI Technical Summary

Problems solved by technology

For the damage caused by heavy ion radiation to the human body, the existing detection methods mainly include MTT colorimetry, flow cytometry, and chromosome and micronucleus detection methods, but the disadvantage of these methods is that they can only detect the degree of radiation damage from the cellular level , unable to study the molecular mechanism and microscopic changes of radiation damage

[0003] Using the principle of molecular changes after heavy ion radiation to select molecular markers for diagnosis / detection of heavy ion radiation is a promising diagnostic method for heavy ion radiation that can overcome the above-mentioned defects to a large extent, but the selection of specific detection molecules (Molecular markers) need to pay attention to the following two issues: first, the sensitivity and specificity of detecting molecular changes, and the dose required to induce molecular changes should be small; It is necessary to reflect the entire radiation exposure dose in a timely manner

Therefore, it is difficult to select all molecular markers that meet the above conditions to evaluate the damage of previous radiation exposure or low dose rate radiation exposure

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