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Flos chrysanthemi composition and application thereof

The technology of a composition and chrysanthemum extract is applied in the direction of drug combination, plant raw materials, anhydride/acid/halide active ingredients, etc., which can solve the problems of drug side effects and limit the use range, so as to prolong the time of swimming with weight and reduce fatigue. Rat serum urea nitrogen content and the effect of reducing serum lactic acid content

Active Publication Date: 2018-03-06
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, for clinical symptoms such as sleep disturbance and fatigue caused by physical and mental fatigue, sleep medicine or benzodiazepine and other anti-anxiety drugs are generally used for relief and treatment, but these drugs are limited due to certain side effects and drug dependence. its scope of use

Method used

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  • Flos chrysanthemi composition and application thereof
  • Flos chrysanthemi composition and application thereof
  • Flos chrysanthemi composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of chrysanthemum extract:

[0025] Select chrysanthemums with complete flower buds, sessile leaves, and no mildew and rot, rinse them with clean water, add 90°C pure water (water: chrysanthemum = 40:1) to soak for 40 minutes, filter the chrysanthemum liquid with 4 layers of gauze, and then filter it Add 90°C purified water (water: filter residue = 40:1) to the filter residue of the above solution and soak for 40 minutes, filter with 4 layers of gauze to obtain two chrysanthemum liquids, combine the two chrysanthemum liquids, and cool to room temperature. The combined chrysanthemum liquid was concentrated 5 times in vacuum with a rotary evaporator at 70°C, the concentrated solution was centrifuged, and the supernatant was freeze-dried at -40°C for 36 hours to make a freeze-dried powder of the chrysanthemum extract, which was set aside (each 10g extract was equivalent to in 200g chrysanthemum raw medicinal material).

Embodiment 2

[0026] The preparation of embodiment 2 chrysanthemum composition granules:

[0027] Get 360g of freeze-dried powder of chrysanthemum extract obtained in Example 1, 100g of wheat seedling powder, and 200g of taurine after mixing, add appropriate amount of starch, dextrin, and glucose and stir evenly to obtain a soft material with suitable elasticity and moderate hardness. , extruded and granulated, dried at 50-60°C for 5-6 hours, put the dried granules at room temperature, passed through a 18-mesh sieve for granulation, and obtained dry granules, which can be packed in separate bags, each bag is 10g, and each bag contains chrysanthemum Composition 4.5~5.0g.

[0028] Take the above chrysanthemum composition granules orally, once a day in the morning and evening, 1 bag each time. 4 weeks is a course of treatment, generally 1 to 2 courses of treatment are markedly effective, 2 months to 6 months can be basically cured.

Embodiment 3

[0029] The preparation of embodiment 3 chrysanthemum composition tablet:

[0030] Get the freeze-dried powder 360g of the chrysanthemum extract that embodiment 1 makes, wheatgrass powder 140g, taurine 180g after mixing evenly, add appropriate amount of starch, dextrin, magnesium stearate, mix and make wet granule and pass tablet press machine Pressed into tablets, the tablet weighs 1.0g, and each tablet contains 0.45-0.50g of the chrysanthemum composition.

[0031] Take the above-mentioned chrysanthemum composition tablet orally, once a day in the morning and evening, 5-10 tablets each time. 4 weeks is a course of treatment, generally 1 to 2 courses of treatment are markedly effective, 2 months to 6 months can be basically cured.

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Abstract

The invention discloses a flos chrysanthemi composition. The flos chrysanthemi composition comprises the following raw materials in parts by weight: 5 to 15 parts of flos chrysanthemi extract, 2 to 5parts of wheat seedling flour and 3 to 10 parts of taurine. The invention further discloses application of the flos chrysanthemi to resist fatigue. Various raw materials of the flos chrysanthemi composition disclosed by the invention are taken, conventional auxiliary materials are added and prepared into clinically acceptable preparations, preferably, tablets, granules and effervescent tablets according to the conventional pharmaceutical method. According to the invention, the flos chrysanthemi extract, the wheat seedling flour and the taurine are taken as effective components, and scientifically and reasonably matched to prepare the flos chrysanthemi composition. The flos chrysanthemi composition disclosed by the invention can significantly prolong the weight-loading swimming time of miceto reduce the serum lactic acid content of fatigue exercise mice, lower the serum urea nitrogen content of the fatigue exercise mice and increase the hepatic glycogen content of the fatigue exercisemice, thereby having a significant role in the aspect of improving body fatigue resistance and being capable of being used in the aspect of anti-fatigue drugs.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a chrysanthemum composition and its application. Background technique [0002] Fatigue is a common problem in modern society. It is neither a state of health nor a state of disease. It is called a sub-health state. A global survey by the World Health Organization shows that only 5% of people are truly healthy, 20% are suffering from diseases, and 75% are in a sub-health state. Most of the patients who go to the fatigue clinic are between 20 and 40 years old, and most of them are young people in their 30s, with an equal ratio of men and women. Most of these patients are highly educated intellectuals, and there are also successful businessmen and business owners. The reasons are mostly related to the fast pace of life, irregular life, high pressure from work and study, mental stress and so on. The impact of fatigue or sub-health on people's li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P39/00A61K31/185
CPCA61K31/185A61K36/287A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 庞晓斌谢欣梅韩光刘富甲田子夏王乐乐魏召艺郭姗姗
Owner HENAN UNIVERSITY
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