Drug for treating obesity and preparation method thereof

A technology of obesity and drugs, applied in the medical field, can solve the problems of large adverse reactions and side effects of chemicals, lack of self-confidence, attraction of the opposite sex, and unsustainable effects, etc., and achieve the effect of no toxic side effects, fast onset of effect, and sustained effect

Inactive Publication Date: 2018-03-06
罗昌兴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, obese people often lack self-confidence and attraction to the opposite sex, resulting in heavy psychological pressure
[0003] The current popular weight-loss drugs are divided into two categories: western medicine and traditional Chinese medicine. Among them, western medicine is a chemical drug represented by sibutramine or orlistat. Although it has a rapid and significant weight-loss effect, the inherent adverse reactions and Accompanying side effects are relatively large; although traditional Chinese medicine for weight loss has the advantages of less adverse reactions and less side effects, it has problems such as easy rebound after taking effect, and long-lasting effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method for treating obesity, comprising the following steps:

[0022] Step 1: Orlistat 130g, phenformin 30g, microcrystalline cellulose 280g, crospovidone 60g, copovidone 110g, silicon dioxide 18g, magnesium stearate 24g, film coating agent 18g, hydroxyl Promellose 25g, talcum powder 5g and triacetin 4g;

[0023] Step 2: Add orlistat, phenformin, microcrystalline cellulose, crospovidone, copovidone, silicon dioxide and magnesium stearate into a mixer and mix for 30 minutes to obtain a mixture;

[0024] Step 3: Compress the mixture obtained in step 2 with a tablet machine, and the tablet weight is 1.2g / tablet;

[0025] Step 4: Add hypromellose, talcum powder, glyceryl triacetate and water into the slurry mixing pan at a mass ratio of 1:2, stir for 45 minutes, put the tablet obtained in step 2 into the coating pan, and adjust The distance between the spray gun and the tablet bed, the spray gun is located in the middle of the coating pan, adjust the atomiza...

Embodiment 2

[0027] A preparation method for treating obesity, comprising the following steps:

[0028] Step 1: Orlistat 90g, phenformin 60g, microcrystalline cellulose 180g, crospovidone 90g, copovidone 90g, silicon dioxide 24g, magnesium stearate 18g, film coating agent 24g, hydroxyl Promellose 15g, talcum powder 10g and triacetin 6g;

[0029] Step 2: Add orlistat, phenformin, microcrystalline cellulose, crospovidone, copovidone, silicon dioxide and magnesium stearate into a mixer and mix for 20 minutes to obtain a mixture;

[0030] Step 3: Compress the mixture obtained in step 2 with a tablet machine, and the tablet weight is 1.2g / tablet;

[0031] Step 4: Add hypromellose, talcum powder, glyceryl triacetate and water into the slurry mixing pan at a mass ratio of 1:3, stir for 45 minutes, put the tablet obtained in step 2 into the coating pan, and adjust The distance between the spray gun and the tablet bed, the spray gun is located in the middle of the coating pot, adjust the atomizat...

Embodiment 3

[0033] A preparation method for treating obesity, comprising the following steps:

[0034] Step 1: Orlistat 100g, phenformin g55, microcrystalline cellulose 240g, crospovidone 80g, copovidone 100g, silicon dioxide 20g, magnesium stearate 20g, film coating agent 20g, hydroxyl Promellose 20g, talcum powder 5g and triacetin 5g;

[0035] Step 2: Add orlistat, phenformin, microcrystalline cellulose, crospovidone, copovidone, silicon dioxide and magnesium stearate into a mixer and mix for 20-30 minutes to obtain a mixture ;

[0036] Step 3: Compress the mixture obtained in step 2 with a tablet machine, and the tablet weight is 1.2g / tablet;

[0037] Step 4: Add hypromellose, talcum powder, glyceryl triacetate and water into the slurry mixing pan at a mass ratio of 1:2, stir for 35 minutes, put the tablet obtained in step 2 into the coating pan, and adjust The distance between the spray gun and the tablet bed, the spray gun is located in the middle of the coating pan, adjust the at...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and particularly discloses a drug for treating obesity and a preparation method thereof. The drug comprises the following components in partsby weight: 80-150 parts of orlistat, 20-80 parts of phenformin, 150-300 parts of microcrystalline cellulose, 50-100 parts of crospovidone, 80-120 parts of copovidone, 15-25 parts of silicon dioxide,15-25 parts of magnesium stearate, and 25-40 parts of a film capsule agent. The drug for treating obesity has the advantages of fast effect taking speed, durable effect, no bouncing and the like, hasno toxic and side effects, is widely applicable to use by patients with genotype congenital obesity, and patients with obesity caused by later-period influences caused by environment, living style andthe like.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a medicine for treating obesity and a preparation method thereof. Background technique [0002] The World Health Organization has confirmed that obesity is a disease. The number of obese patients in the world is doubling in about 5 years. At present, there are at least 200-500 million obese people in the world, and about 1 billion overweight people. There are about 300 million overweight people over the age of 20 in my country, and more than 40 million obese people. Obesity is often accompanied by "three highs" (hypertension, hyperglycemia, and hyperlipidemia), increasing the incidence of "three diseases" (diabetes, heart disease, and cancer) Chance. More than 80% of diabetics have a history of obesity, and more than 90% will be complicated by cardiovascular and cerebrovascular diseases. More and more studies have shown that obesity can cause the decline of human im...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/155A61P3/10A61P3/04A61K9/36
CPCA61K9/2866A61K31/155A61K31/365A61K2300/00
Inventor 罗昌兴
Owner 罗昌兴
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