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Building of non-human primate dysmenorrheal model and dysmenorrheal pain measuring method

A primate, non-human technology, applied in diagnostic recording/measurement, medical science, sensors, etc., can solve problems such as non-human primate dysmenorrhea pain model reports, etc., to achieve rich experimental animal resources, genetic The effect of clear background and strict quality control

Inactive Publication Date: 2018-02-27
上海浦灵生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] At present, there is no report of non-human primate dysmenorrhea pain model

Method used

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  • Building of non-human primate dysmenorrheal model and dysmenorrheal pain measuring method
  • Building of non-human primate dysmenorrheal model and dysmenorrheal pain measuring method
  • Building of non-human primate dysmenorrheal model and dysmenorrheal pain measuring method

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Embodiment Construction

[0033] specific implementation plan

[0034] In order to enable those skilled in the art to understand the present invention more comprehensively, the present invention will be further described below in conjunction with examples, but the present invention is not limited in any way.

[0035] Experimental animals: female cynomolgus monkeys (Macaca fascicularis) with normal menstruation and appropriate age were selected;

[0036] Main reagents: estrogen and oxytocin;

[0037] Vaginal expansion device: including a flexible expansion unit, a medium loading unit, and a medium loading control unit;

[0038] Measurement monitoring unit: video monitor;

[0039] method:

[0040] a. Regularly and quantitatively inject estrogen to experimental monkeys every day, and inject continuously for several days;

[0041] b. When measuring (see figure 2 ), link the flexible expansion unit of the vaginal expansion device with the medium loading unit, and at the same time dynamically detect th...

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Abstract

The invention relates to a building method of a non-human primate dysmenorrheal model and a measuring principle of non-human primate dysmenorrheal pains. Combined induction of estrogen and oxytocin isutilized to build the non-human primate dysmenorrheal pain model, and a measurement device is utilized to measure the pains. When the device measures the pains, a medium loading unit is connected with a flexible expansion unit through a communication pipe, after the flexible expansion unit is put into the vagina of a primate, mediums are loaded according to a preset procedure to expand the expansion unit, a measuring monitoring unit is connected with the primate and a medium loading controlling unit separately, and by detecting the reaction of the primate to the pains and feeding the reactionback to the medium loading controlling unit, and recording loading data at the same time, the degree of the dysmenorrheal pains is quantitatively measured. As is shown by cases, the measuring methodis high in sensitivity and repeatability. The dysmenorrheal model and the measuring principle and method of the non-human primate dysmenorrheal pains have a wide application range in the relevant field of scientific research, teaching, products and technological development and the like, and can also provide experimental estimation for the development of new drugs for the dysmenorrheal pains.

Description

technical field [0001] The invention relates to the establishment of a pain model, in particular to a method for establishing a hormone-induced non-human primate dysmenorrhea pain model. technical background [0002] Dysmenorrhea refers to lower abdominal pain, swelling, backache and other discomforts before and after menstruation or during menstruation. It is one of the most common gynecological symptoms, especially in female puberty, and its incidence rate is as high as 45%-80%, affecting women's daily life and work. , recurrent or serious can lead to infertility. The manifestations of dysmenorrhea pain are unclear and diverse, lacking consistent objective evaluation criteria. [0003] Existing dysmenorrhea test models are based on some small rodents (such as rats and mice), because rodents are far away from humans in evolutionary relationship, physiological cycle, hormone regulation, nerve distribution, etc. Obtaining dysmenorrhea-related mechanisms and experimental int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B90/00
CPCA61B5/4318A61B5/4827A61B2503/40
Inventor 王立新张红谢蓝夏良泽郭营营王珏荣
Owner 上海浦灵生物科技有限公司
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