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Preparation method of antibacterial peptide gynecologic washing lotion

A peptide gynecological and lotion technology, which is applied in the field of preparation of antibacterial peptide gynecological lotion, can solve the problems of accelerated vaginal aging, long preparation time, lack of synergistic effect, etc., to increase solubility and absorption rate, improve active ingredients and yield , increase the effect of sterilization and anti-inflammation

Active Publication Date: 2018-02-23
吉安市御美丽健康产业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of the lotion is completely different from that of the vaginal secretion. Repeated douching will irritate the vagina, destroy the vaginal secretion environment, accelerate the aging of the vagina, and easily cause vaginal dryness.
[0005] CN101099815A discloses a herbal cleansing lotion and its preparation process. It specifically discloses that a variety of Chinese herbal medicines, royal jelly, vitamin C and other raw materials are mixed to form a vaginal lotion. Dozens of Chinese herbal medicines and royal jelly are expensive and take a long time to prepare , only play their own role, lack of synergistic effect
CN105079405A discloses miconazole nitrate compound lotion and its preparation method. Specifically, it discloses that after extracting and concentrating Chinese medicine components, they are mixed with miconazole nitrate to form a vaginal lotion. Miconazole nitrate can inhibit fungal growth and also inhibit lactic acid Bacteria grows, and it is very irritating when used, and it is easy to damage vaginal tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of antimicrobial peptide gynecological lotion, comprising the following steps:

[0032] 1) Take honeybees, place them in an environment containing Gardnerella and Bacteroides for 1 to 2 hours, then heat at 50°C for 2 hours, dry the whole insects, add licorice tablets, and grind to obtain bee powder; the licorice tablets and honeybees The mass ratio is 1:8; the honeybee is Apis mellifera; the particle diameter of the honeybee powder is 1mm;

[0033] 2) Put the honeybee powder into the glycerin-acetic acid solution containing glucose, soak for 30 hours, and then ultrasonically vibrate for 10 minutes to obtain a mixed solution; the volume fraction of glycerol in the glycerin-acetic acid solution is 15%; The concentration of the solution is 0.5mol / L;

[0034] 3) Filter the mixed solution to remove the filter residue, freeze the filtrate at -10°C first, and then dehydrate and dry it under 2Pa vacuum condition to obtain honeybee extract;

[0035] 4) Pre...

Embodiment 2

[0037] A preparation method of antimicrobial peptide gynecological lotion, comprising the following steps:

[0038] 1) Take honeybees, place them in an environment containing Gardnerella and Bacteroides for 1 to 2 hours, then heat at 70°C for 1 hour, dry the whole insects, add licorice tablets, and pulverize them to obtain bee powder; the licorice tablets and honeybees The mass ratio is 1:10; the honeybee is a high-yielding honeybee of royal jelly; the particle diameter of the honeybee powder is 5mm;

[0039] 2) Put the honeybee powder into glycerol-acetic acid solution containing glucose, soak for 40 hours, and then ultrasonically vibrate for 20 minutes to obtain a mixed solution; the volume fraction of glycerol in the glycerin-acetic acid solution is 30%; The concentration of the solution is 1mol / L;

[0040] 3) Filter the mixed solution to remove the filter residue, freeze the filtrate at -30°C first, and then dehydrate and dry it under 10Pa vacuum condition to obtain the h...

Embodiment 3

[0043] A preparation method of antimicrobial peptide gynecological lotion, comprising the following steps:

[0044] 1) Take honeybees, place them in an environment containing Gardnerella and Bacteroides for 1 to 2 hours, then heat at 60°C for 1.5 hours, dry the whole insects, add licorice tablets, and pulverize them to obtain bee powder; the licorice tablets and honeybee The mass ratio of the honeybee is 1:9; the honeybee is Anatolia honeybee; the particle diameter of the honeybee powder is 1-5mm;

[0045] 2) Put the bee powder into the glycerol-acetic acid solution containing glucose, soak for 35 hours, and then ultrasonically vibrate for 15 minutes to obtain a mixed solution; the volume fraction of glycerol in the glycerin-acetic acid solution is 20%; The concentration of the solution is 0.8mol / L;

[0046]3) Filter the mixed solution to remove the filter residue, freeze the filtrate at -20°C first, and then dehydrate and dry it under 5Pa vacuum condition to obtain honeybee ...

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PUM

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Abstract

The invention discloses a preparation method of an antibacterial peptide gynecologic washing lotion. The preparation method comprises the following steps: (1) culturing bees in an environment containing gardnrella vaginallis and bacteroides fragilis, heating and drying bees, adding licorice tablets, and grinding bees to obtain bee powder; (2) adding bee powder into a glycerin-acetic acid solutioncontaining glucose, soaking, and then carrying out ultrasonic vibration to obtain a mixed solution; (3) filtering the mixed solution, removing the filter residues, and dry-freezing the filtrate to obtain a bee extract; and (4) adding the bee extract and vitamin C into cucumber juice, stirring, then adding a MgSO4 solution, and stirring to obtain the washing lotion. The prepared antibacterial peptide gynecologic washing lotion can be absorbed by the patients peacefully, the pathogenic bacteria are killed, and at the same time, a comfortable and healthy environment is created for the growth andproliferation of beneficial bacteria.

Description

technical field [0001] The invention relates to the field of gynecology, in particular to a preparation method of antibacterial peptide gynecological lotion. Background technique [0002] Under the action of endocrine hormones in the vagina of healthy women, the epithelial cells proliferate, and the surface cells are rich in glycogen, which is conducive to the growth of Lactobacillus, which accounts for more than 90% of the vagina. The presence of a large number of such lactobacilli inhibits the growth of other pathogenic bacteria and forms a normal ecological balance in the vagina. [0003] When a large number of external pathogens invade and destroy the defense function of the vagina, the microecological balance of the normally parasitic vaginal flora becomes imbalanced, beneficial bacteria such as Lactobacillus in the vagina decrease while other bacteria proliferate in large numbers, and anaerobic bacteria reproduce and produce amines and alkalis at the same time. Vagina...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K38/02A61K9/00A61K47/46A61K47/22A61K47/02A61P15/02A61P31/04
CPCA61K9/0034A61K35/63A61K38/02A61K47/02A61K47/22A61K47/46
Inventor 尹志明刘动勤彭松涛
Owner 吉安市御美丽健康产业股份有限公司
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