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Homogenous polysaccharide with immunoregulatory activity and preparation method thereof

An immunoregulatory and active technology, applied in the directions of organic active ingredients, medical preparations containing active ingredients, food ingredients containing polysaccharide/gum, etc. Effects of immune function

Active Publication Date: 2018-02-16
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

We also have related research on the immunomodulatory effect and mechanism of Polyporus polysaccharides, but the above research objects are all Polyporus polysaccharides, and did not involve a specific component in Polyporus homogeneous polysaccharides and its immune-related activities

Method used

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  • Homogenous polysaccharide with immunoregulatory activity and preparation method thereof
  • Homogenous polysaccharide with immunoregulatory activity and preparation method thereof
  • Homogenous polysaccharide with immunoregulatory activity and preparation method thereof

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Embodiment Construction

[0041] The present invention is described in further detail now in conjunction with accompanying drawing. These drawings are all simplified schematic diagrams, which only illustrate the basic structure of the present invention in a schematic manner, so they only show the configurations related to the present invention.

[0042]In this application, the homogeneous polysaccharide can be composed of the polysaccharide extracted from Polyporus polyporus and pharmaceutical excipients, wherein the monosaccharide of the polysaccharide is α-D-glucopyranose, and can also be isolated from other fungi and plants, or by using microorganisms The homogeneous polysaccharides obtained by fermentation, artificial synthesis and other means as long as they have the molecular weight and physical and chemical spectral properties; the effect: significantly promote the secretion of macrophage NO, significantly increase the macrophage IL-1β, IL-6, TNF-α and iNOS gene and iNOS, COX-2 protein expressio...

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Abstract

The invention relates to a homogenous polysaccharide with immunoregulatory activity and a preparation method thereof. The homogenous polysaccharide with immunoregulatory activity has a single chromatographic peak, and has a molecular weight of 6880+ / -5 Da, and an optical rotation value of 158.4+ / -0.5 degrees; the infrared spectrum has a characteristic absorption peak at 847.6 cm<-1>; the hydrogenproton chemical shift in a hydrogen spectrum are respectively delta 5.40brs, 3.95t, J=7.2Hz, 3.84m, and 3.61m; and the chemical shift of the carbon signals in a carbon spectrum are respectively delta99.6, delta76.6, delta73.3, delta71.5, delta71.1 and delta60.4. The homogenous polysaccharide can enhance the immune function of organism, has very good anti-tumor, anti-virus, and anti-infection effects when immune-related diseases are adjusted and summarized, and has a potential development value in the industry of medicine health-care products for treating and preventing diseases.

Description

technical field [0001] The invention relates to the technical field of homogeneous polysaccharides, in particular to homogeneous polysaccharides with immune regulation activity and a preparation method thereof. Background technique [0002] Some traditional Chinese medicine polysaccharides have the functions of activating immune cells and improving the immune function of the body, and have attracted the attention of many researchers for their advantages such as definite effects and low toxic and side effects. As an immunomodulator with development potential, it will play a huge role in the process of eliminating diseases and enhancing human resistance. However, most studies on polysaccharides in traditional Chinese medicine are limited to total polysaccharides, and the specific molecular composition and mechanism of action are not clear. Sugar medicinal substances. [0003] Polyperus polysaccharide is the main active ingredient in the Chinese medicine Polyporus polysacchar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02A61P37/02A61P35/00A61P31/12A61P31/00A61P39/06A61P29/00A23L33/125
CPCA23V2002/00A23L33/125C08B37/0003C08B37/0009A23V2200/30A23V2200/324A23V2250/51A61K31/716A61P31/12A61P35/00A61P37/02
Inventor 曾星黎雄刘春萍
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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