Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-myocardial-ischemia traditional Chinese medicine composition and preparation method and application thereof

An anti-myocardial ischemia and composition technology, applied in the field of traditional Chinese medicine pharmacy, can solve problems such as poor curative effect, and achieve the effects of improving curative effect, simple raw materials, and simple preparation method

Active Publication Date: 2018-02-16
裴一非
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of myocardial ischemia, Western medicines developed with a single target, such as nitrates, calcium ion blockers, and β-receptor blockers, are mostly used at present. The characteristic is that it can exert multi-target, multi-link and multi-level pharmacological effects, and has potential advantages in the treatment of myocardial ischemia and other diseases with complex etiology. Blood medicine is an effective way

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-myocardial-ischemia traditional Chinese medicine composition and preparation method and application thereof
  • Anti-myocardial-ischemia traditional Chinese medicine composition and preparation method and application thereof
  • Anti-myocardial-ischemia traditional Chinese medicine composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A preparation method of a traditional Chinese medicine composition for resisting myocardial ischemia, comprising:

[0051] 1) Weigh Jincao, Agrimony and Fenxinmu according to the weight ratio of 1:2:1, and mix them uniformly to obtain a Chinese medicine mixture;

[0052] 2) Take the traditional Chinese medicine mixture obtained in 1), and extract it by the reflux extraction method with a volume fraction of 55% ethanol, and the liquid-to-solid ratio is 17mL·g -1 , reflux extraction twice, 146min each time, extraction temperature 85-100°C, filter the extract, combine, and concentrate the filtrate to 0.5g·mL under reduced pressure -1 , dilute with water, the amount of water used in the dilution with water is 0.5-1 times of the weight of the filtrate after concentration, 3000r·min after standing -1 Centrifuge for 0.5-5min, and the supernatant is the total flavonoid extract;

[0053] 3) Load the total flavonoid extract obtained in 2) onto an AB-8 macroporous adsorption res...

experiment example

[0055] The specific embodiment of the present invention adopts reflux extraction technology, the total flavonoids extracted in this way is higher than the ultrasonic extraction method, and the ethanol reflux extraction process of compound total flavonoids is optimized by response surface method, wherein the single factor test is investigated as follows:

[0056] (1) Ethanol volume fraction: Accurately weigh 6 parts of the compound formula (Dijincao 10.0g, Agrimony 20.0g, Fenxinmu 10.0g), and then according to the texture of the medicinal materials and the properties of the extracted target components, this formula The texture of the medicinal material is crisp and loose, adding too little extract is not enough to submerge the medicinal material, and the target components to be extracted are flavonoids, including flavonoid aglycones and flavonoid glycosides, which cannot be fully extracted with more polar water, and the extraction time will be too long. damage to ingredients. T...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an anti-myocardial-ischemia traditional Chinese medicine composition and preparation method and application thereof. The traditional Chinese medicine composition is made fromherba euphorbiae humifusae, hairyvein agrimonia herb, and diaphragma juglandis at a weight ratio of (1-3):(1-6):(1-3). The composition adopts natural herbal medicines as raw materials, wherein the natural herbal medicines are simple and available. The preparation method is simple, stable, and feasible. The prepared total flavonoids extract has an obvious effect on resistance of myocardial ischemia, is non-toxic or harmless to the human body, and accords with national policies and legislations.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for resisting myocardial ischemia, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Myocardial ischemia is a complex disease with multiple etiologies. It is a pathological state in which myocardial energy metabolism is abnormal and the heart cannot work normally due to the reduction of blood supply and oxygen supply to the heart. As the initial stage of various heart diseases, it induces Myocardial infarction, angina pectoris, arrhythmia and other heart diseases seriously threaten human health and quality of life. The pathogenesis of myocardial ischemia is relatively complex, and many bioactive molecules and intracellular signal transduction pathways are involved in reactive oxygen species, calcium overload, inflammation, and apoptosis. For the treatment of myocardial ischemia, Western medici...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/73A61P9/10A23L33/105
CPCA23V2002/00A61K36/47A61K36/52A61K36/73A61K2236/333A61K2236/51A61K2236/55A23L33/105A61K2300/00A23V2200/326A23V2250/21
Inventor 裴一非程艳刚
Owner 裴一非
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com