Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antitumor application of echo viruses used as oncolytic viruses

A virus, virus genome technology, applied in the field of biomedicine

Inactive Publication Date: 2018-02-09
邹罡
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the sensitivity of different serotypes of echoviruses to the oncolytic activity of tumor cells. The present invention attempts to discover the specificity of different serotypes of echoviruses in treating tumors through research, so as to provide more anti-tumor drug regimens. Safe and Effective Solutions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antitumor application of echo viruses used as oncolytic viruses
  • Antitumor application of echo viruses used as oncolytic viruses
  • Antitumor application of echo viruses used as oncolytic viruses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0070] 1. Materials

[0071] Cell Lines and Cell Culture

[0072] LLC-MK2 (rhesus kidney cells), A549 (human non-small cell lung cancer cells), MCF7 (human breast cancer cells), SW620 (human colon cancer cells), DU 145 (human prostate cancer cells), NCI-N87 ( Human gastric cancer cells), HuH-7 (human liver cancer cells), HeLa 229 (human cervical cancer cells), A-375 (human malignant melanoma cells), MIA PaCa-2 (human pancreatic cancer cells), RD (human malignant embryonic rhabdomyoma cells), SK-OV-3 (human ovarian cancer cells), U-87MG (human astroglioblastoma cells), the above cell lines were purchased from the Chinese Academy of and 10% fetal bovine serum (fetal bovine serum, FBS) DMEM medium, at 37 ° C, 5% CO 2 cultured in an incubator.

[0073] Virus

[0074]ECHO1 Farouk strain (ATCC VR-31), ECHO3 Morrisey strain (ATCC VR-33), ECHO4 Pesascek strain (ATCC VR-34), ECHO5 Noyce strain (ATCC VR-35), ECHO6D'Amori strain (ATCC VR-36), ECHO7Wallace strain (ATCC VR-37), ECHO9H...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses antitumor application of echo viruses used as oncolytic viruses. The antitumor application particularly includes application of the echo viruses ECHO1, ECHO3, ECHO4, ECHO5, ECHO6, ECHO7, ECHO9, ECHO11 and ECHO25 to lung cancer, colon cancer, prostate cancer, gastric cancer, liver cancer, pancreatic cancer and rhabdomyoma. The antitumor application has the advantages that different levels of oncolytic activity of the different echo viruses for different types of tumor cells are proved, and accordingly the fact that the echo viruses can be used for specifically treating tumor is prompted.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of echovirus as an oncolytic virus in anti-tumor. Background technique [0002] Oncolytic viruses are a type of virus that tends to infect tumor cells, and can multiply in large numbers in tumor cells, eventually causing tumor cells to lyse, break up, and die. Since the first genetically engineered oncolytic virus was reported in 1991, a variety of oncolytic viruses have entered clinical trials in the following 20 years. The first oncolytic virus drug Ankerui (recombinant human adenovirus type 5 H101) was approved by the China Food and Drug Administration in 2005. It is used in combination with chemotherapy for advanced refractory nasopharyngeal carcinoma. Amgen's oncolytic virus product T-Vec was approved by the US FDA in October 2015, and was approved by the EU CHMP in December of the same year for the treatment of advanced inoperable melanoma. The launch of T-Vec furt...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K35/768A61P35/00A61K31/7105A61K31/711
CPCA61K31/7105A61K31/711A61K35/768A61K2300/00
Inventor 邹罡
Owner 邹罡
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com