Method for improving safety of compound rhizoma corydalis decumbentis injection solution

An injection and safety technology, applied in the field of medicine, achieves the effect of high safety, improved safety and good safety

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium benzoate is also added to the domestically produced compound summer-free injection as a co-solvent, facing the same problem

Method used

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  • Method for improving safety of compound rhizoma corydalis decumbentis injection solution
  • Method for improving safety of compound rhizoma corydalis decumbentis injection solution
  • Method for improving safety of compound rhizoma corydalis decumbentis injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation method: add water to decoct snow lotus and snow lotus twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Yinlan is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative densi...

Embodiment 2

[0024]

[0025] Preparation method: add water to decoct snow lotus and snow lotus twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Yinlan is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative densi...

Embodiment 3

[0027]

[0028] Preparation method: add water to decoct snow lotus and snow lotus twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Yinlan is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative densi...

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Abstract

The invention discloses a method for improving the safety of compound summer injection. According to the method, the pharmaceutical composition for injection is mainly prepared from the extracts of summer grass, snow lotus extract, silver orchid extract and enteric-coated acrylic resin. The method of the present invention adopts the co-solvent sodium benzoate that security is better, the solubilizing effect is more obvious to replace the co-solvent sodium benzoate that has potential safety hazard and influence product quality in compound summer non-injection, and the safety of enteric-coated acrylic resin is higher than sodium benzoate and The dosage is lower, reducing the probability and risk of adverse drug reactions, and improving the safety of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for improving the safety of compound summer-free injection. Background technique [0002] The standard of the compound summer-free injection is recorded in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine), and the raw materials are summer-free, snow lotus, and Yinlan, which belong to the traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Xiawu injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/19A61K9/08A61K47/32A61P15/00A61P29/00
CPCA61K36/285A61K9/0019A61K9/08A61K9/19A61K36/66A61K36/898A61K47/32A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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