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Method for improving safety of compound radix angelicae sinensis injection solution

A technology for injection and safety, which is applied in the field of medicine to achieve the effect of improving safety, low dosage, and reducing the probability and risk of adverse reactions

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound angelica injection produced in China also adds phenoxyethanol as a co-solvent, facing the same problem

Method used

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  • Method for improving safety of compound radix angelicae sinensis injection solution
  • Method for improving safety of compound radix angelicae sinensis injection solution
  • Method for improving safety of compound radix angelicae sinensis injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation method: decoct angelica and astragali with water twice, each time for 2 hours, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C), a...

Embodiment 2

[0024]

[0025] Preparation method: decoct angelica and astragali with water twice, each time for 2 hours, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C), a...

Embodiment 3

[0027]

[0028] Preparation method: decoct angelica and astragali with water twice, each time for 2 hours, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C), a...

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Abstract

The invention discloses a method for improving the safety of compound angelica injection. The method mainly prepares a pharmaceutical composition for injection from angelica extract, astragalus extract, notoginseng extract and methyl methacrylate. The method of the present invention adopts the co-solvent with better safety and more obvious solubilizing effect to replace the co-solvent phenoxyethanol which has potential safety hazards and affects product quality in the compound angelica injection, and the safety of methyl methacrylate is higher than that of phenoxyethanol Moreover, the dosage is lower, which reduces the probability and risk of adverse drug reactions and improves the safety of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for improving the safety of compound angelica injection. Background technique [0002] The standard of compound angelica injection is recorded in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine), and the raw materials are angelica, astragalus, and notoginseng, which belong to traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Angelica Injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of tradition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/08A61K47/14A61K47/10A61P15/00A61P29/00
CPCA61K36/232A61K9/0019A61K9/08A61K36/258A61K36/481A61K47/10A61K47/14A61K2236/331A61K2236/39A61K2300/00
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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