Small animal integrated radiotherapy system fusing computed tomography (CT) and positron emission tomography (PET) bimodal image guidance

Abstract

The present invention provides a small animal integrated radiotherapy system fusing CT and PET bimodal image guidance, and belongs to the detection imaging equipment technology field. The system comprises a PET imaging system, an X-ray CT imaging system, an animal bed system, a to-be-detected object, a radiotherapy system, a data acquisition system, a control system and a computer, integrates theadvantages of the CT and PET bimodal imaging, and utilizes a high-resolution anatomical structure image of the CT imaging and the molecular image information provided by the PET imaging to position atumor accurately. The system is an integrated system of the image guidance and the radiotherapy, realizes the accurate radiotherapy of the tumor, at the same time, carries out the monitoring and evaluation of the molecular level on a tumor radiotherapy effect, thereby providing an efficient preclinical research platform for the tumor radiotherapy research, establishing a bridge for the animal experiment and the clinical transformation, and accelerating the clinical transformation progress.

Description

technical field [0001] The invention belongs to the technical field of detection and imaging equipment, and in particular relates to an integrated radiotherapy system for small animals guided by dual-mode images of CT and PET. Background technique [0002] Small animals play a crucial role in the research and testing of new radiotherapy methods, especially when the cellular level cannot be simulated and human trials cannot be performed, such as the influence of the tumor microenvironment, the bystander effect induced by high-dose radiotherapy, gene expression The impact of radiotherapy, the optimal time point of radiotherapy combined with immunotherapy, and the side effects of radiotherapy in normal tissues. However, the large-area, single-beam radiotherapy irradiation mode is widely used in small animal radiotherapy experiments, which is far from the three-dimensional image-guided precise local radiotherapy technology used in clinical radiotherapy. Because there is no imag...

AI Technical Summary

Problems solved by technology

However, there is no integrated system with CT and PET dual-mode imaging functions for guiding precise radiotherapy for small animals

[0004] Although CT or CBCT plays an indispensable role in precise radiotherapy for small animals, CBCT has poor contrast to soft tissues and cannot clearly distinguish the location of tumors in situ such as brain, liver, pancreas, and prostate, and CT cannot detect radiotherapy. The response of tumors at the cellular and molecular levels undoubtedly restricts the implementation of precise radiotherapy and the evaluation of radiotherapy effects.

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