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Pharmaceutical compound preparation for treating glomerulonephritis

A technology of glomerulonephritis and compound preparations, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of low healing efficiency and insignificant therapeutic effect, and achieve convenient administration and remarkable therapeutic effect , the effect of less sequelae

Inactive Publication Date: 2018-01-16
CHENGDU LINGXI SHANGPIN TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing treatment methods are traditional Chinese medicine therapy, and most of them use Yishen Decoction, Yiwenwen Shenhuoxue Decoction, Yiwenwen Shenhuoxue Decoction, Qingzhuo Shenfu Decoction, Wuchong Decoction, etc. to carry out internal adjustment of the human body to achieve remission of the disease. The efficiency is low, and the therapeutic effect is not significant
At present, there is no related drug compound preparation for the treatment of glomerulonephritis.

Method used

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  • Pharmaceutical compound preparation for treating glomerulonephritis
  • Pharmaceutical compound preparation for treating glomerulonephritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The compound oral preparation of this embodiment is prepared by a method known in the pharmaceutical industry, and the specific dosage of each component is shown in Table 1:

[0018] Table 1 The specific dosage of each component

[0019]

[0020]

[0021] The treatment effect of using the combination of two oral drugs of pre-furadan and vancomycin at the same time shows that the effect of using pre-furadan and vancomycin is better than that of a single drug, which is a reasonable combination for the development of two drugs. The compound preparation used has laid the foundation.

Embodiment 2

[0023] Validation of therapeutic effect in rat model:

[0024] Objective: To observe the effect of different ratios of compound preparations of profuradin combined with vancomycin on rats with DOCA (deoxycorticosterone acetate) suffering from glomerulonephritis, so as to explore the therapeutic effect of different doses of the compound.

[0025] Methods: 1200 SD rats, ♂, body weight 180-190g. After resecting the right kidney under aseptic conditions, DOCA 5mg / cattle was administered twice a week, sc, and fed with 1% sodium chloride solution; they were randomly divided into 12 groups, 8 in each group, and the specific grouping and treatment were shown in the table two.

[0026] Table 2 Animal grouping and drug formulation, administration method

[0027] model group

normal saline

Profuradan group

Profuradan 400 mg

vancomycin high group

Vancomycin 40 mg

compound group

Profuradan 20 mg, vancomycin 2 mg

Compound two group

P...

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Abstract

The invention discloses a pharmaceutical compound preparation for treating glomerulonephritis. The compound preparation comprises the following components in parts by weight: 10 to 300 parts of nitrofurantoin, 10 to 120 parts of vancomycin, and 10 to 1600 parts of drug carrier. Nitrofurantoin and vancomycin are taken as the pharmaceutical components and mixed with the drug carrier to prepare the compound preparation. The compound preparation is convenient to take, is very safe, has a prominent effect, can greatly reduce complications, generates few sequelae, barely causes adverse reactions, and promotes the healing.

Description

technical field [0001] The invention relates to the field of drug compound preparations, in particular to a drug compound preparation for treating glomerulonephritis. Background technique [0002] Chronic nephritis, short for chronic glomerulonephritis, is a common but refractory chronic kidney disease. It is clinically characterized by edema, proteinuria, hematuria, and high blood pressure. The disease is most common in young and middle-aged people, and the incidence rate of men is higher than that of women. In recent years, it has been found that the incidence rate of the elderly is also on the rise. The etiology and pathogenesis of chronic nephritis are still controversial, but most doctors believe that this disease is an immune response disease related to infection, especially beta-hemolytic streptococcal infection, and modern medicine still lacks a clear understanding of this disease. ideal therapy. [0003] Most of the existing treatment methods are traditional Chine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/14A61K31/4178A61P13/12A61P31/04
Inventor 姜迪蛟
Owner CHENGDU LINGXI SHANGPIN TECH CO LTD
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