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Applications of xenon or xenon gas mixture in preparing preparations for treating epilepsy

A technology of gas mixtures and preparations, applied in the directions of drug delivery, drug combination, medical preparations containing active ingredients, etc., can solve problems such as damage to normal brain function, damage to brain tissue, limitations of surgical treatment, etc., and achieve significant treatment and neuroprotection effect, the effect of resolving drug resistance

Active Publication Date: 2018-01-12
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because epilepsy has the characteristics of multiple foci and unclear foci, many epilepsy patients are not suitable for surgical treatment, and often surgery will inevitably destroy normal brain tissue and eventually damage normal brain function
In addition, brain injury is one of the important causes of epilepsy, so a considerable proportion of surgical patients relapsed epilepsy a few years after surgery, so surgical treatment is also greatly limited
However, there is no report on xenon as a therapeutic gas for the treatment of epilepsy.

Method used

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  • Applications of xenon or xenon gas mixture in preparing preparations for treating epilepsy
  • Applications of xenon or xenon gas mixture in preparing preparations for treating epilepsy
  • Applications of xenon or xenon gas mixture in preparing preparations for treating epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Research on the antiepileptic effect of xenon

[0037] 1. Test method:

[0038] (1) The classic epilepsy animal model KA was injected into the lateral ventricle to prepare the acute epileptic seizure model, and different components of gas were inhaled once after KA administration. 70% xenon / 30% oxygen (xenon group) and 70% nitrogen / 30% oxygen (KA group) were continuously inhaled for 2 hours, and behavioral and EEG data were recorded.

[0039] (2) The acute epileptic seizure model induced by KA. Immediately after KA administration, 70% xenon / 30% oxygen was given once (xenon group), and the other group was given 70% nitrogen / 30% oxygen once (KA group); After 7 days, the animal mortality was counted.

[0040] 2. Test results:

[0041] The effect of xenon treatment on the duration of animals' residence in various grades of epilepsy can be found in figure 1 ,Depend on figure 1 It can be seen that within 60 minutes of KA-induced acute epileptic seizures, the c...

Embodiment 2

[0049] Example 2: Effects of Xenon Treatment on Cell Apoptosis During Epilepsy

[0050] This experimental study found that in the rat epilepsy model induced by intracerebroventricular injection of KA, at different time points (24h, 3d, 7d), in multiple areas of the brain (such as cortex, hippocampus), Actived caspase-3 / GAPDH (classical apoptosis Index) significantly increased (P Figure 4 ). Figure 4 Among them, A is the apoptosis changes at different time points after KA-induced epilepsy; B is the apoptosis changes at different time points after xenon treatment; C is the analysis of apoptosis changes at different time points after KA-induced epilepsy; D is the apoptosis changes at different time points after xenon treatment analyze. As shown in the figure above, at different time points (24h, 3d, 7d) in the KA-induced grand mal epilepsy model, the apoptosis index Actived caspase-3 / GAPDH in the brain was significantly higher than that of the Shame group; while xenon treatment...

Embodiment 3

[0052] Example 3: Effect of xenon gas treatment on autophagy in KA-induced acute epileptic seizure model

[0053] This experimental study found that KA-induced acute epileptic seizures in rats at different time points (24h, 3d, 7d), LC3Ⅱ / GAPDH (LC3Ⅱ / LC3Ⅰ or LC3Ⅱ / GAPDH is often used to evaluate the level of autophagy) in each area of ​​the brain is not obvious However, after xenon gas treatment, the LC3Ⅱ / GAPDH in the cortex and hippocampus increased significantly (P Figure 5 ); Figure 5 Among them, A is the change of autophagy function at different time points after KA-induced epilepsy; B is the change of autophagy function at different time points after xenon gas treatment; C is the change of autophagy index in different brain regions and at different time points in each group. As shown in the figure above, at different time points (24h, 3d, 7d) of the KA-induced grand mal epilepsy model, different regions of the brain (C: cortex; P: piriform cortex; H: hippocampus), xenon tr...

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Abstract

The invention discloses applications of xenon or a xenon gas mixture in preparing preparations for treating epilepsy. Specifically, the invention relates to the following applications of xenon, wherein epilepsy is caused by paradoxical discharge of neurons, xenon can inhibit paradoxical discharge of the neurons and enhance the autophagy function of cells, and thus the inhibiting effect for occurrence and development of epilepsy is realized. According to the technical scheme, the fact that xenon or the xenon gas mixture has the obvious treatment and nerve protection effects for epilepsy is found for the first time, the difficulties including the drug tolerance generated by oral administration of medicines for treating epilepsy and the uncertainty caused by surgical treatment for epilepsy are overcome, meanwhile, the safety for xenon is proved in the application as an anesthetic, and therefore, a novel thought and a novel treatment medicine are provided for the treatment for epilepsy.

Description

technical field [0001] The present invention relates to the use of xenon in the preparation of therapeutic gas, in particular to the use of xenon or xenon gas mixture in the preparation of preparations for treating epilepsy. Background technique [0002] Epilepsy is a chronic disease of transient brain dysfunction caused by sudden abnormal discharge of brain neurons. According to Chinese epidemiological data, the overall prevalence of epilepsy in China is 7.0‰, the annual incidence is 28.8 / 100,000, and the prevalence of active epilepsy with seizures within one year is 4.6‰. Based on this, it is estimated that there are about 9 million epilepsy patients in China, of which 5 to 6 million are active epilepsy patients, and about 400,000 new epilepsy patients are added every year. In China, epilepsy has become the second most common disease in neurology after headache. sick. [0003] At present, there are mainly two methods for the treatment of epilepsy, drug therapy and surgic...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K9/72A61P25/08
Inventor 孙红柳朱伟
Owner BINZHOU MEDICAL COLLEGE
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