Trace identification method for natural Russian musk and natural forest musk

Abstract

The invention relates to the fields of pharmaceutical analysis and traditional Chinese medicine identification and particularly relates to a trace identification method for natural Russian musk and natural forest musk. The method comprises a sample pretreatment step and a combined GC-MS chromatographic analysis and data treatment step. GC-MS color spectra of the natural Russian musk and the natural forest musk are contrastively analyzed, and the type of the musk can be determined by virtue of the significant difference of characteristic peaks of muscone in two types of musk and the comparisonof analysis data of the contents of muscone in two types of musk, so that the natural Russian musk and the natural forest musk can be conveniently, rapidly and accurately analyzed and judged. The operation specification and conditions of the method are specific, and the influence caused by the subjective factor of people is low, so that the accuracy and reliability of a result are remarkably improved; and furthermore, the method is simple, convenient and feasible, low in requirements on the professional level and practical experience of an operator and is vey suitable for being popularized andused in the field of pharmaceutical detection.

Description

technical field [0001] The invention relates to the fields of drug analysis and identification of traditional Chinese medicines, in particular to a micro-identification method for natural Russian musk and natural forest musk. Background technique [0002] Natural musk is a very precious Chinese herbal medicine. It has the effects of resuscitating the mind, promoting blood circulation and dredging collaterals, reducing swelling and relieving pain, etc. It has a long medicinal history of more than 2,000 years, and has played a long-term and important role in the history of medical care of the Chinese nation. Not only that, natural musk can also be used to make high-grade spices. [0003] Musk is produced in the sac glands of male musk deer, which is the dry secretion in the mature male musk sac, and forest musk is mainly used in traditional Chinese medicine. Forest musk deer is a national first-class protected animal. With the reduction of the number of wild forest musk deer ...

AI Technical Summary

Problems solved by technology

Forest musk deer is a national first-class protected animal. With the reduction of the number of wild forest musk deer in China, the production of forest musk musk has dropped sharply in recent years. At present, the production of natural musk deer in China mainly depends on artificial breeding of forest musk deer, but its demand and stock are very unbalanced. , resulting in an extreme shortage of domestic natural musk, the supply of musk in the market is in short supply, and the price is also rising year by year

In this context, various foreign musks, especially Russian musks, began to be smuggled into the country and sold as forest musk. Compared with forest musk, Russian musk has a large output and low value. Large-scale counterfeiting has seriously disrupted the normal domestic musk market. At the same time, it also had a negative impact on the domestic musk deer industry

[0004] On the other hand, the pharmacological activity of Russian musk is far inferior to that of forest musk. Using Russian musk imitating forest musk as medicine will significantly reduce the efficacy of the medicine, which is extremely unfavorable to the treatment of patients' diseases.

[0005] However, because Russian musk is very similar to forest musk in terms of appearance, color and smell, it is difficult to distinguish it from forest musk through the identification of appearance, color, and smell. This is why Russian musk is so popular important reason for

[0006] At present, the identification of Russian musk is mainly to judge whether it is Russian musk by observing the appearance of the sachet gland before the musk is taken out of the sachet gland. However, once the musk is taken out of the sachet gland, it is extremely difficult to make an accurate determination of its original source. judged

[0007] Also some scholars have proposed the method (Fu Ying etc., on-the-spot rapid microscopic identification of the authenticity of musk, Journal of Pharmaceutical Analysis, 2012, 32 (4): 706-708) by the method for discriminating domestic forest musk musk and Russian musk by microscopic observation method, but Since the difference in the appearance of forest musk and Russian musk is not obvious under the microscope, the detection accuracy of the microscopic observation method needs to be improved, and the microscopic observation method needs to be operated by professionals who have undergone long-term training. The level and practical experience requirements are relatively high, and the judgment of the observation results is easily affected by the subjective factors of the observers, so it is difficult to popularize and use

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