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Traditional Chinese medicine granules for treating cataract and preparation method thereof

A technology of traditional Chinese medicine granules and cataracts, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of large dosage, limited clinical application, inconvenient carrying and transportation, etc., to reduce the dosage and reduce the daily cost. Dosage, low hygroscopicity effect

Inactive Publication Date: 2018-01-05
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese invention patent "A Traditional Chinese Medicine for Treating and Delaying the Progression of Age-Related Cataract" (publication number CN102526341) discloses a kind of Buqing Decoction, which has a definite curative effect on early and middle age-related cataracts, but the dosage is large, and it is difficult to carry and transport Inconvenience and other disadvantages limit its clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Raw material composition, by weight:

[0029] 20 parts of Rehmannia glutinosa, 15 parts of Lycium barbarum, 12 parts of Plantago, 15 parts of Cuscuta, 12 parts of Digupi, 20 parts of Poria cocos, 12 parts of chamomile.

[0030] Preparation method (secondary granulation - wet granulation method):

[0031] 1) Pulverize each of the above-mentioned raw medicinal materials separately, and pass through 20 meshes for later use.

[0032] 2) Weigh each raw material in step 1) according to the above ratio, mix them evenly, put them into an extraction tank, add deionized water 8 times the total mass of the raw materials, and extract at 100°C for 1 hour, filter the extract, and concentrate under reduced pressure to Density is 1.05, add 8% (mass ratio) dextrin, spray and freeze-dry, the liquid feeding speed is 5 mL / min, the vortex speed is 6.8 m / s, and the temperature is -100°C, and the extract powder microcapsules are obtained .

[0033] 3) Take 50 parts of the above extract pow...

Embodiment 2

[0035] Raw material composition, by weight:

[0036] Rehmannia glutinosa 15 parts, medlar 10 parts, plantago 9 parts, dodder 10 parts, Digupi 10 parts, Poria cocos 15 parts, chamomile 10 parts.

[0037] Preparation method (secondary granulation - wet granulation method):

[0038] 1) Pulverize each of the above-mentioned raw medicinal materials separately, and pass through 20 meshes for later use.

[0039] 2) Weigh each raw material in step 1) according to the above ratio, mix them evenly, put them into an extraction tank, add deionized water 8 times the total mass of the raw materials, extract at 100°C for 2 hours, extract twice, and concentrate under reduced pressure to The density is 1.20, add 2% (mass ratio) hypromellose-β-cyclodextrin, and carry out spray freeze-drying. That is the extract powder microcapsules.

[0040] 3) Take 50 parts of the above-mentioned extract powder, 10 parts of dextrin, 10 parts of microcrystalline cellulose, 1 part of lactose, 2 parts of manni...

Embodiment 3

[0042] Raw material composition, by weight:

[0043] Rehmannia glutinosa 25 parts, wolfberry fruit 20 parts, plantago seed 15 parts, dodder seed 20 parts, Digupi 14 parts, Poria cocos 25 parts, chamomile flower 14 parts.

[0044] Preparation method (secondary granulation - wet granulation method):

[0045] 1) Pulverize each of the above-mentioned raw medicinal materials separately, and pass through 20 meshes for later use.

[0046] 2) Weigh each raw material in step 1) according to the above ratio, mix them evenly, put them into an extraction tank, add deionized water 8 times the total mass of the raw materials, extract at 100 °C for 2 hours, extract 3 times, filter the extract, Combined, concentrated under reduced pressure to a density of 1.00, added 6% (mass ratio) stearic acid, and carried out spray freeze-drying, the liquid feeding speed was 12 mL / min, the vortex speed was 10 m / s, and the temperature was -105 °C, namely Obtain extract powder microcapsules.

[0047] 3) T...

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Abstract

The invention relates to traditional Chinese medicine granules for treating cataract and other eye diseases and a preparation method thereof. Effective constituents of the traditional Chinese medicinegranules are traditional Chinese medicine extract powder which is prepared from, by weight, 15-25 parts of rehmanniae radix praeparata, 10-20 parts of lycii fructus, 9-15 parts of semen plantaginis,10-20 parts of cuscutae semen, 10-14 parts of lycii cortex, 15-25 parts of poria and 10-14 parts of camomile. The traditional Chinese medicine granules are prepared through a secondary granulation technology, have the advantages of being uniform in granule size, high in shaping rate, low in hygroscopicity, convenient to take and precise in curative effect, and are suitable for industrial production and clinical application.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine granule for treating cataract and other related diseases and a preparation method thereof. Background technique [0002] Currently, cataract is the leading cause of blindness worldwide and the leading cause of vision loss in the elderly. According to the report of the World Health Organization, by 2020, there will be more than 40 million blind patients worldwide due to cataract, which is also the main cause of blindness among the middle-aged and elderly people in my country. Impaired vision has brought a lot of inconvenience to the life of the elderly and seriously affected the quality of life of the elderly. There is currently no effective drug treatment, and surgery is the only way. However, subject to geographical and economic development and other factors, vision restoration surgery has not yet been fully popularized. Using drugs t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/16A61P27/12
Inventor 牛阳左文宝王荣杨建宏
Owner NINGXIA MEDICAL UNIV
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