Methods and compositions for early cancer testing and cancer diagnosis before the clinical symptoms of malignant diseases and the method and component
A cancer, malignant technology, applied in chemical instruments and methods, biochemical equipment and methods, analytical materials, etc., can solve problems such as undetermined cell surface ENOX2 cancer specificity
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Embodiment 1
[0137] Example 1. As determined by 2-D gel electrophoresis / immunoblotting analysis, the two-fold increase in the spot size and density of different amounts of ENOX2 in the assay, compared with no NADH in the presence of 15 μM NADH incubation ( figure 1 ).
Embodiment 2
[0138] Example 2. Analysis of sera from 1,626 cancer patients with diagnosed cancer (Table 1, reproduced from Summary of the Invention) showed transcript variants (Protein 1 to Non-overlapping patterns of protein3) quantities, molecular weights, and isoelectric points.
[0139] Table 1, reproduced from Summary of the Invention: Molecular weight (MW) and isoelectric point (Pi) ranges determined for sera from patients diagnosed with 24 different cancers representing 20 different tissues of origin
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[0141]
[0142] * Blood cell cancers include lymphomas, leukemias, and myelomas expressed as totals.
[0143] **Non-small cell lung cancer in two subsets to avoid molecular weight overlap with small cell lung cancer.
[0144] ***Uterine cancer in two subsets based on molecular weight to avoid overlap with bladder cancer (see footnotes 1 and 2).
[0145] 1. The isoelectric point pH of protein 1 ≥ protein 2.
[0146] 2. The isoelectric point pH of protein 1 < protein 2...
Embodiment 3
[0147] Example 3. The ONCOblot test correctly identifies cancers based on tissue of origin with stage 0 and stage I cancers (Table 3). Stage 0 and I cancers are often called carcinoma in situ, and the disease has not spread beyond the tissue in which it originated. Therefore, the ONCOblot cancer test indicates cancer earlier than the circulating tumor cell test, which detects only cancer cells in the blood.
[0148] Table 3. Tissues of origin for stage 0 and stage I cancers analyzed
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