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Drug particle loaded degradable catheter

A catheter and drug technology, applied in the field of degradable catheter method, can solve the problems of long degradation and absorption time, slow degradation speed, weak cell adhesion, etc., and achieve the effect of good hydrophilicity, low production and operation costs, and short degradation time

Active Publication Date: 2017-12-12
成都迪康中科生物医学材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a large number of studies have shown that polylactic acid materials have the following problems in practical applications: 1) the hydrophilicity is not enough, and the adhesion to cells is weak; 2) the degradation rate is slow, and the degradation and absorption time is very long (generally 3 to 5 years).

Method used

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  • Drug particle loaded degradable catheter
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Preparation of β-chitosan / polylactic acid composite material

[0032] A) Preparation of polylactic acid: It includes two steps S1 to S2:

[0033] S2. Preparation of lactide: using 85wt% of D,L-lactic acid as raw material, anhydrous zinc oxide as catalyst, heating to 110°C, vacuum distillation, then rapid heating to 220°C, vacuum distillation, The distilled fraction is washed with ethyl acetate and recrystallized to obtain D,L-lactide;

[0034] S2. Synthesis of polylactic acid: Weigh the D,L-lactide prepared in the above steps and place it in a clean ampere flask, and inject 0.2% by mass of D,L-lactide into a chloroform solution of stannous octoate as a trigger Evacuated, the bottle mouth is fused and sealed, placed in an oil bath at a temperature of 150°C, and polymerized for 25 hours to obtain polylactic acid with a number average molecular weight of 65,000;

[0035] B) Preparation of composite material: Take the polylactic acid prepared above, dissolve it in an o...

Embodiment 2

[0042] Example 2. Degradable catheter of the present invention

[0043] Embodiment 1 of the present invention provides a degradable catheter for loading drug particles, which includes a connecting portion 1, a first lumen 2 and a second lumen 3 provided at both ends of the connecting portion for containing drug particles 4. The connecting portion is used to connect the first lumen 301 and the second lumen 302. The connecting portion only serves as a connection. It can be of any shape, as long as it can achieve the purpose of connecting the first lumen and the second lumen. Within the scope of the connecting portion of the present invention, preferably, the connecting portion is preferably cylindrical. Preferably, the diameter of the connecting portion is 0.8-1.8 mm, and more preferably, the diameter of the connecting portion is 1.2 mm. The length of the connecting portion is preferably 10-40 mm, more preferably 25 mm. The first lumen and the second lumen are preferably cylindri...

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Abstract

The invention belongs to the field of medical apparatus and instruments, and specifically relates to a drug particle loaded degradable catheter. The drug particle loaded degradable catheter comprises a connecting part, a first catheter chamber and a second catheter chamber, wherein the first catheter chamber and the second catheter are correspondingly formed in two ends of the connecting part and used for storing drug particles. According to the drug particle loaded degradable catheter, a plurality of catheters are connected through the drug particles, and the drug particles are kept in consistent intervals in the catheters; meanwhile, additional separating blocks are not arranged in the catheters; the drug particle loaded degradable catheter is simple and convenient to mount and operate, low in production and operation cost, and applicable to wide-scope popularization and application. Additionally, the connecting parts, the first catheter chamber and the second catheter chamber in the catheter are prepared from a beta-chitosan / polylactic acid composite material which is a degradable material and is short in degrading time and high in hydrophilia.

Description

Technical field [0001] The invention belongs to the field of medical equipment, and specifically relates to a degradable catheter method for loading drug particles. Background technique [0002] For tumor treatment, it is not only required to effectively kill tumor cells and improve survival rate, but also to ensure the quality of life of patients. The traditional method of systemic anti-tumor therapy has short half-life, difficulty in maintaining effective concentration for a long time, high systemic toxicity and poor patient tolerance. The local placement of the drug implantation can not only increase the drug concentration at the tumor target site, but also increase the efficacy of the drug while reducing the drug consumption, thereby reducing the adverse drug reactions and systemic toxicity. However, it is difficult and time-consuming to implant the drug into the tumor site accurately and in accordance with a reasonable location plan, and sometimes even requires a second imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10A61M31/00A61M25/00A61L29/12A61L29/14A61L29/16
CPCA61L29/126A61L29/148A61L29/16A61L2300/416A61M25/0023A61M25/0043A61M31/00A61M2205/02A61N5/1002A61N5/1007A61N2005/101A61N2005/1024C08L5/08C08L67/04
Inventor 王进王一夫谢强周鹏王仪振
Owner 成都迪康中科生物医学材料有限公司
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