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Exocarpium citri grandis extract and application thereof to preparation of anti-cancer drug

An anti-cancer drug and orange red technology, which is applied in the direction of drug combination, anti-tumor drug, digestive system, etc., to achieve the effect of favorable drug safety, significant anti-liver cancer effect, clear active ingredients and content

Active Publication Date: 2017-12-08
AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing anti-cancer reports, most of the medicinal materials of Huajuhong are used as one of the medicinal materials to treat cancer, and there is no report of using the effective part of Huajuhong alone as an anticancer drug.

Method used

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  • Exocarpium citri grandis extract and application thereof to preparation of anti-cancer drug
  • Exocarpium citri grandis extract and application thereof to preparation of anti-cancer drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 orange red extract

[0027] (1) Take Huajuhong, heat and reflux extraction with 95% ethanol aqueous solution for 1.5h by volume fraction, and concentrate the extract to obtain Huajuhong ethanol extract;

[0028] (2) Dissolve the ethanol extract of Citrus Red in water into a suspension, first extract with an equal volume of petroleum ether, repeat the extraction 3 times, discard the petroleum ether extract, then extract with an equal volume of ethyl acetate, and repeat the extraction for 3 times Once, the concentrated ethyl acetate extracts were combined to obtain the orange red extract;

[0029] (3) Enriching the active ingredients of the orange-red extract through silica gel column chromatography to obtain the orange-red extract;

[0030] The method for enriching active ingredients by silica gel column chromatography is as follows: put the citronella extract on a silica gel column (the weight of the silica gel used in the silica gel col...

Embodiment 2

[0034] The preparation of embodiment 2 chrysanthemum extract

[0035] (1) Take Huajuhong, heat and reflux extraction with 95% ethanol aqueous solution for 1.5h by volume fraction, and concentrate the extract to obtain Huajuhong ethanol extract;

[0036] (2) Dissolve the ethanol extract of Citrus Red in water into a suspension, first extract with an equal volume of petroleum ether, repeat the extraction 3 times, discard the petroleum ether extract, then extract with an equal volume of ethyl acetate, and repeat the extraction for 3 times Once, the concentrated ethyl acetate extracts were combined to obtain the orange red extract;

[0037] (3) Enriching the active ingredients of the orange-red extract through silica gel column chromatography to obtain the orange-red extract;

[0038] The method for enriching active ingredients by silica gel column chromatography is as follows: put the citronella extract on a silica gel column (the weight of the silica gel used in the silica gel ...

Embodiment 3

[0040] The preparation of embodiment 3 chrysanthemum extract

[0041] (1) Take Huajuhong, heat and reflux extraction with 95% ethanol aqueous solution for 1.5h by volume fraction, and concentrate the extract to obtain Huajuhong ethanol extract;

[0042] (2) Dissolve the ethanol extract of Citrus Red in water into a suspension, first extract with an equal volume of petroleum ether, repeat the extraction 3 times, discard the petroleum ether extract, then extract with an equal volume of ethyl acetate, and repeat the extraction for 3 times Once, the concentrated ethyl acetate extracts were combined to obtain the orange red extract;

[0043] (3) Enriching the active ingredients of the orange-red extract through silica gel column chromatography to obtain the orange-red extract;

[0044] The method for enriching active ingredients by silica gel column chromatography is as follows: put the citronella extract on a silica gel column (the weight of the silica gel used in the silica gel ...

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Abstract

The invention relates to the technical field of medicinal chemistry, and particularly discloses an exocarpium citri grandis extract and application thereof to preparation of an anti-cancer drug. The extract is prepared from the following active ingredients in percentage by weight: 30% to 40% of nobiletin, 20% to 30% of kaempferol and 20% to 30% of rhoifolin. The exocarpium citri grandis extract disclosed by the invention is definite in active ingredient and content and obvious in anti-hepatoma effect.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a citrus red extract and its application in the preparation of anticancer drugs. Background technique [0002] Huajuhong, that is, Huazhou Juhong, comes from the immature or nearly mature dry outer peel of the Rutaceae plant Huazhou pomelo or pomelo. It has the effect of resolving phlegm and relieving cough, and treating wind-cold cough. [0003] Liver cancer is a malignant tumor of the liver, which can be divided into two categories: primary and secondary. Primary hepatic malignant tumors originate from the epithelial or mesenchymal tissues of the liver. The former is called primary liver cancer. [0004] In the existing anti-cancer reports, most of the medicinal materials of Huajuhong are used as one of the medicinal materials to treat cancer, and there is no report of using the effective part of Huajuhong alone as an anticancer drug. For example, a traditional C...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/352A61P35/00A61P1/16
CPCA61K31/352A61K31/7048A61K36/752A61K2300/00
Inventor 吴铿郭润民姜佳美莫海亮游琼
Owner AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIV
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