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Composition and application thereof in treatment of liver cancer

A technology for the treatment of liver cancer and its composition, applied in the field of medicine, can solve the problems that there are no research reports on the synergistic effect of aplysia and β-carotene on liver cancer

Active Publication Date: 2015-11-04
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no research report on the synergistic effect of aplysia and β-carotene on liver cancer

Method used

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  • Composition and application thereof in treatment of liver cancer
  • Composition and application thereof in treatment of liver cancer
  • Composition and application thereof in treatment of liver cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 a composition

[0047] Raw materials (molar ratio):

[0048] β-carotene: Aplysia = 1:3

Embodiment 2

[0049] Example 2 a composition

[0050] Raw materials (molar ratio):

[0051] β-carotene: Aplysia = 1:2.6

Embodiment 3

[0052] Example 3 a composition

[0053] Raw materials (molar ratio):

[0054] β-carotene: Aplysia = 1:2

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PUM

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Abstract

The present invention provides a composition comprising vitamin A or a prodrug thereof, and aplysin; the molar ratio of vitamin A or the prodrug thereof to aplysin is 1:0.1-3; the vitamin A or the prodrug thereof is preferably beta-carotene. The present invention also provides the pharmaceutical composition and the application of the composition containing vitamin A or prodrug thereof, and aplysin in the preparation of medicament for treatment of liver cancer. The synergistic effect of the active ingredients in the composition can effectively inhibit the proliferation of liver cancer cells.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composition comprising aplysia and vitamin A or its prodrug and its medical application in treating liver cancer. Background technique [0002] Hepatocellular carcinoma is one of the most common malignant tumors in China, which has the characteristics of insidious onset, high metastasis rate, and poor prognosis. Although surgery is the first choice and the most effective method for the treatment of liver cancer, chemotherapy is one of the main methods of treatment for inoperable patients. Some patients can also get the chance of surgery because of chemotherapy, which prolongs their lives and improves their quality of life. However, while chemotherapy drugs kill tumor cells, they also cause serious damage to normal cells in the body. Therefore, searching for a highly effective and low-toxic anticancer drug has become the focus of attention in recent years. [0003] Aplysia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P35/00A61P1/16A61K31/07
Inventor 刘颖梁惠贺娟韩磊
Owner QINGDAO UNIV
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